Reduction reactions are cornerstone tools in organic synthesis, enabling chemists to convert carbonyl groups to alcohols, nitro compounds to amines, and alkynes to alkenes with unparalleled selectivity. From asymmetric hydrogenation to deoxygenation strategies, name reactions pioneered by leading chemists provide robust pathways to streamline synthetic workflows. At Alfa Chemistry, we equip researchers with premium reductants, catalysts, and technical expertise to master these transformative processes. Explore key reduction name reactions below to refine your synthetic toolkit.
Key Reduction Name Reactions
Barton-McCombie Deoxygenation
Removes hydroxyl groups via radical-mediated reduction of thiocarbonyl derivatives, critical for deoxygenating sugars and natural products.
Birch Reduction
Reduces aromatic rings to 1,4-cyclohexadienes using liquid ammonia and alkali metals, pivotal in steroid and alkaloid synthesis.
Bouveault-Blanc Reduction
Converts esters to primary alcohols using sodium and ethanol, a classical method for fatty acid derivatives.
Brown Hydroboration
Adds boron to alkenes asymmetrically via BH3-THF, enabling anti-Markovnikov alcohol synthesis after oxidation.
Clemmensen Reduction
Reduces ketones or aldehydes to alkanes using zinc amalgam and HCl, ideal for acid-stable substrates.
Corey-Bakshi-Shibata Reduction
Asymmetrically reduces ketones to chiral alcohols using oxazaborolidine catalysts, essential in enantioselective synthesis.
Meerwein-Ponndorf-Verley Reduction
Transfers hydrogen from alcohols to ketones via aluminum alkoxides, preserving acid-sensitive functional groups.
Rosenmund Reduction
Catalytically reduces acyl chlorides to aldehydes using poisoned palladium, preventing over-reduction to alcohols.
Wolff-Kishner Reduction
Converts carbonyl groups to methylene via hydrazine and strong base, suitable for acid-sensitive substrates.
Fukuyama Reduction
Reduces thioesters to aldehydes using a triethylsilane-palladium system, avoiding over-reduction to alcohols.
Borch Reductive Amination
Combines ketones/aldehydes with amines using NaBH3CN to form secondary/tertiary amines, central to drug discovery.
Chan Alkyne Reduction
Also known as red aluminum-mediated alkyne reduction, a stereoselective method for converting alkynols (alkynols) to trans-(E)-allyl alcohols.
