Fluorinated Building Blocks

Fluorinated Building BlocksFluorinated building blocks are compounds containing negatively charged fluorine, which are used for preparing compounds. Although the abundance of fluorine in the crust is ranked 13th, it is the most abundant halogen in nature. Due to the electronegativity, atomic radius and polarizability of fluorine atoms, fluorinated compounds usually have the unique physical, chemical and physiological properties.

Therefore, the preparations and the applications of fluorinated compounds have aroused widespread interest of scientists, and they are widely used in material chemistry, medicinal chemistry, organic chemistry and biochemistry.

Alfa Chemistry provides a wide variety of fluorinated building blocks including heterocyclic fluorinated building blocks and organic fluorinated compounds.


  • Material chemistry: Fluoropolymer materials have many special properties and are used in a very wide range of applications. In 1938, Polytetrafluoroethylene (PTFE), discovered by Dr. Plunkett at Dupont, which became the beginning of the research and application of fluoropolymers. Polytetrafluoroethylene is insoluble in any acid, base and organic solvents, and it forms only a tough, transparent gel that does not flow even when it melts. At present, the applications of PTFE have expanded from the initial national defense fields such as aviation, spaceflight, and military industry to various fields of national economy such as petrochemicals, machinery, electronic appliances, construction, textile, and so on, so PTFE is famous as "The King of Plastic".

  • Fluorinated Building Blocks

    Other fluorinated compounds also have many applications in the electronics industry. Some fluorine-containing gases are used as etchants in the plasma etching process for making microchips. In a word, liquid crystal materials, computer monitors, laptops and cell phones can not be manufactured without fluorinated liquid crystal material.

  • Medicinal chemistry: Fluorinated compound in medicinal chemistry can be used as anesthetic. Fluoroxene (2,2,2-trifluoroethyl vinyl ether) is the first fluoro-containing anesthetic for human use and has led to the "fluoride revolution" in the field of anesthesiology. Perfluorocarbons and perfluorinated ethers can also be used as artificial blood and respiratory fluids due to their excellent oxygen solubility, innocuity, and physiological inertness. Perfluorocarbon-based blood substitutes can replace the patient's blood during surgery and provide oxygen for the body. After the operation is completed, the patient's blood is then input into the body and the residual blood substitutes are excluded through the lungs in a few days or weeks.

  • Agricultural chemistry: Fluoro pesticide is important in the field of pesticides, such as cotoran, trifluralin, oxyfluorfen, herbicide, fluoride aphid locust, diflubenzuron, and fluorine containing pyrethroids pesticides are the typical fluoro pesticides. The introduction of fluorine to the pesticides improves their performance further. Such as herbicides pyridine fluff grass Ling (Sturm) with fluorine-containing pyridine derivatives performance more than doubled than the previous herbicides.

  • Fluorinated Building Blocks

  • Organic chemistry: Organic fluorine intermediates include aromatic fluorides and aliphatic fluorides. Aromatic fluorides are important intermediates for the synthesis of pharmaceuticals, pesticides and dyes, such as 2,4-dichlorofluorobenzene for the synthesis of anti-infective quinolones ciprofloxacin, fluoxacine, and norfloxacin; p-fluorophenol for the synthesis of anti-inflammatory and anti-rheumatoid drug sopineil; fluorobenzoyl chloride for the synthesis of cardiovascular and cerebrovascular drugs fluvastatin sodium; 3-chloro-4-fluoroaniline for the synthesis of fluoroquinolone antibiotics; 4-Bromo-2-fluoroaniline for the synthesis of anti-inflammatory drug ibuprofen.

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