Organic building block is a term in organic chemistry, which is used to describe an organic compound with functional groups. Organic building blocks are mainly used for bottom-up modular assembly of metal-organic frameworks, organic molecular constructs, and supra-molecular complexes. Using organic building blocks ensures strict control of what a final compound will be.
Alfa Chemistry can offer a wide variety of organic building blocks including alkanes, alkenes, alkynes, arenes, arsenic compounds, carbonyl compounds, halogenated hydrocarbons, nitrogen compounds, organic phosphine compounds, organic silicon compounds, oxygen compounds and selenium compounds.
Organic building blocks are used in many fields as follow:
Medicinal chemistry: In medicinal chemistry, organic building blocks are organic functionalized molecules that selected for the use in modular synthesis of novel drug candidates. And organic building blocks should be either mono-functionalised or possessing selectively chemically addressable functional groups so that they can be practically useful for the modular drug or drug candidate assembly. One of the major strategies for pharmaceutical industry involved in drug discovery is the use of organic building blocks prepared for fast and reliable constructions of small molecular compounds for biological screening. Usually, one-step synthesis of compounds from building blocks is, in most cases, faster and more reliable than multistep synthesis of target compounds.
Organic chemistry: Organic building blocks are the basic components for organic synthesis. For example, fluoromalonate esters are versatile fluorinated building blocks that can be used for the introduction of fluorine atoms into aliphatic and aromatic heterocyclic systems. The study on syntheses of fluoromalonate compounds using commercially available fluorinating reagents on research and manufacturing scales is described, and the use of fluoromalonates for appropriate alkylation, acylation, Michael addition, annelation, and biotransformation processes is also presented, providing access to the synthesis of novel selectively fluorinated structures (Fig.1).
Material chemistry: Utilizing organic building blocks is an effective strategy to synthesize materials. Simple molecule structures such as etraphenylethene (TPE) is an archetypal luminogen that are widely used in the construction of luminogenic materials and in the research and development of new organic light emitting diodes (OLEDs), solid-state lasers, photoconductive and photovoltaic devices and nonlinear optics materials. The simplicity of manufacture, arising from the fact that organic building blocks are processable either as the starting materials or as a precursor, thus allowing the possibility of tuning the material's optical and electronic properties by using the enormous versatility of organic chemistry, has allowed the different applications of practical relevance.
Fig. 1. Synthesis of fluoromalonates using N-fluorobenzenesulfonimide (NFSI)