In vitro toxicology stands at the forefront of modern drug discovery, providing indispensable insights into the safety and efficacy of pharmaceutical compounds. By harnessing the power of cell-based assays and advanced technologies, in vitro toxicology enables researchers to predict potential adverse effects early in the drug development process, thereby minimizing risks and accelerating the path to market.
Our Services
At Alfa Chemistry, we are committed to excellence in in vitro toxicology services, offering a comprehensive suite of assays tailored to meet the diverse needs of our clients. Our portfolio encompasses a wide range of toxicity screening assays, including:
Cytotoxicity Screening
Our state-of-the-art assays, utilizing techniques such as LDH release and ATP content measurement, allow for precise quantification of cell viability and death, enabling early detection of cytotoxic compounds.
Genotoxicity Screening
Our assays, including the bacterial reverse mutation test (AMES assay) and the in vitro mammalian micronucleus test (MNT), are designed to detect various types of genotoxic events, from point mutations to chromosomal aberrations, with high sensitivity and specificity.
Cardiotoxicity Screening
Our rapid hERG Predictor fluorescence polarization assay enables efficient screening of compounds for their potential to interact with the hERG channel, a key determinant of cardiac function.
Mechanistic Toxicity Assays
Our assays for mitochondrial toxicity, oxidative stress, and apoptosis induction provide valuable insights into the cellular pathways affected by drug exposure, facilitating informed decision-making in drug development.
Hematologic Toxicology
Hematologic toxicity, including hemolysis, can have serious implications for the safety of intravenous drug formulations. Our in vitro hemolysis assay allows for the detection of potential hemolytic effects of drugs and their metabolites, ensuring the safety of parenteral administration routes.
In addition to our core in vitro toxicology services, we offer a range of complementary services to support the drug development process. These include in vitro metabolism studies, evaluation of drug-drug interactions, and assessment of transporter inhibition, providing our clients with a comprehensive suite of solutions to address their drug safety needs.
Our Strengths
- Cutting-Edge Technologies
We leverage the latest advancements in cell culture, imaging, and analytical techniques to ensure the accuracy and reproducibility of our assays.
- Expertise and Experience
Our team of experienced scientists possesses a wealth of expertise in in vitro toxicology and drug development. With years of experience in designing and executing complex assays, we are well-equipped to tackle even the most challenging toxicological questions.
- Customized Solutions
Whether it's developing custom assays or optimizing existing protocols, we work closely with our clients to deliver solutions that align with their objectives and timelines.
- Regulatory Compliance
Our assays are conducted in accordance with OECD guidelines and other relevant regulatory standards, providing our clients with confidence in the reliability and integrity of our data.
At Alfa Chemistry, we are dedicated to providing cutting-edge in vitro toxicology services that enable our clients to make informed decisions and bring safe and effective drugs to market. Contact us today to learn more about our services and discover how we can empower your journey towards innovation and success.