Hexatriacontane

• CAS: 630-06-8
• Catalog Number: ACM630068
• Category: Main Products
• Molecular Weight: 506.97
• Molecular Formula: C₃₆H₇₄
• Synonyms: N-HEXATRIACONTANE;HEXATRIACONTANE;ALKANE C36;hextriacontane; ;N-HEXATRIACONTANE, 1000MG,NEAT;HEXATRIACONTANE, STANDARD FOR GC;n-Hexatriacontane,97+%;Hexatriacontane,98%
• IUPAC Name: hexatriacontane
• SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
• InChI Key: YDLYQMBWCWFRAI-UHFFFAOYSA-N
• Boiling Point: 265°C1mm Hg(lit.)
• Melting Point: 74-76°C(lit.)
• Flash Point: 497°C
• Density: 0.7795
• Appearance: white flakes
• EC Number: 211-127-8
• Exact Mass: 506.57900
• Safety Description: S24/25
• WGK Germany: 3

Case Study

Hexatriacontane Transfersomal Gel for Topical Antibacterial Therapy in Skin Infections

Aodah, Alhussain H., et al. Gels 9.4 (2023): 322.

Hexatriacontane, a naturally occurring long-chain alkane isolated from various plant species, has demonstrated antimicrobial properties in preliminary studies. However, its extreme hydrophobicity and poor aqueous solubility have limited its bioavailability and therapeutic applicability as a topical antimicrobial agent.
Experimental Protocol: Hexatriacontane-loaded transethosomes (HTC-TES) were developed using the rotary evaporator technique and optimized via a three-factor, three-level Box-Behnken design. The optimized formulation was characterized for vesicle morphology, in vitro drug release using the dialysis bag method, and release kinetics fitting. A transethosomal gel was prepared and evaluated for texture profile and spreadability. Dermatokinetic studies and confocal laser scanning microscopy (CLSM) using rhodamine B were performed on rat skin to assess depth of penetration. Antimicrobial activity was tested against S. aureus and E. coli at 10 mg/mL.
Performance Evaluation: The optimized HTC-TES formulation (lipoid 90 mg, ethanol 25%, sodium cholate 10 mg) achieved a particle size of 183.9 nm, PDI of 0.262, zeta potential of -26.61 mV, and entrapment efficiency of 87.79%. In vitro release studies showed that HTC-TES achieved 74.67% drug release over 24 h, substantially exceeding the 38.75% release from the conventional HTC suspension. The Higuchi model provided the best fit, and the Korsmeyer-Peppas model indicated non-Fickian diffusion. The formulated gel exhibited favorable cohesiveness (-118.29) and good spreadability. Dermatokinetic analysis demonstrated significantly enhanced HTC transport into epidermal layers compared to conventional formulation gel. CLSM imaging confirmed deeper penetration of 30.0 µm for the rhodamine B-loaded TES formulation versus 0.15 µm for the hydroalcoholic solution. The HTC-loaded transethosome gel effectively inhibited growth of both S. aureus and E. coli at 10 mg/mL.

Hexatriacontane-Tricosane Binary Mixtures as Phase Change Materials for Thermal Storage

Zimmermann, Jana, et al. Thermal Advances (2026): 100131.

Phase change materials (PCMs) are essential for thermal energy storage and micro actuator technologies. N-alkane blends offer a promising route to tailor thermophysical properties such as melting temperature and heat of fusion.
Experimental Protocol: Binary mixtures of tricosane (C23, purity >99%) and hexatriacontane (C36, purity >98%) were prepared gravimetrically at various compositions, then melted at 90 degrees C and solidified at room temperature. DSC measurements were conducted using a 3D Calvet calorimeter over a temperature range of 30 to 80 degrees C at heating rates of 0.05 and 0.1 K/min, with sample masses from 10 to 135 mg. The calorimeter was calibrated using a four-point calibration with high-purity metals. Peak deconvolution by Gauss-Lorentz cross function resolved overlapping transitions.
Performance Evaluation: For pure tricosane, four phase transitions were observed: delta-transition at 36.7 degrees C, order-disorder at 38.9 degrees C, rhombohedral II at 42.7 degrees C, and melting at 46.2 degrees C, with a total enthalpy of 223.9 J/g. Pure hexatriacontane exhibited three transitions: crystal-crystal at 70.6 degrees C, order-disorder at 71.6 degrees C, and melting at 73.5 degrees C, with approximately 245 J/g total enthalpy. In binary blends, the hexatriacontane melting peak shifted by over 17 K depending on composition, while tricosane peak temperatures shifted by no more than 3 K, demonstrating selective tunability. Total enthalpy deviated slightly from the composition-weighted ideal, with a maximum reduction of 6%. These findings confirm that small additions of tricosane can selectively lower the phase transition temperature of hexatriacontane with only minor enthalpy losses, enabling fine temperature tuning of PCMs.

Hexatriacontane in Leaf Epicuticular Wax as Short-Range Insect Attractant

Mobarak, Syed Husne, et al. Journal of Applied Entomology 144.7 (2020): 616-631.

Green gram, Vigna radiata, is an important pulse crop in Asia, but severe defoliation by larvae of the Bihar hairy caterpillar, Spilosoma obliqua Walker, significantly reduces seed yield. Female moths rely on leaf surface cues to locate host plants and select oviposition sites. Understanding the chemical basis of this host recognition could inform the development of behavior-based pest management tools.
Experimental Protocol: Leaf surface waxes from three green gram cultivars (PDM 54, PUSA BAISAKHI, and SAMRAT) were extracted using n-hexane dipping. N-alkanes were fractionated by thin-layer chromatography and analyzed by GC-MS and GC-FID. Free fatty acids were similarly purified, esterified, and analyzed. Y-tube olfactometer bioassays were conducted with gravid S. obliqua females to test behavioral responses toward one leaf equivalent surface wax, individual synthetic compounds, and synthetic blends against solvent controls.
Performance Evaluation: Analyses identified 20 n-alkanes (n-C15 to n-C36) and 13 free fatty acids (C12:0 to C21:0) in leaf surface waxes of the three cultivars, with linoleic acid uniquely present in SAMRAT. Pentacosane was the predominant n-alkane across all cultivars. Total alkane content was highest in PDM (16.41 mg/25 g leaf). In olfactometer assays, females showed significant attraction to crude leaf waxes of all three cultivars against solvent controls. Individual compounds eliciting attraction included pentacosane, hexatriacontane, palmitoleic acid, linolenic acid, and stearic acid. Synthetic blends mimicking the active wax components of each cultivar were equally attractive as the corresponding crude wax. In oviposition assays, females laid significantly more eggs on intact leaves and crude wax-treated surfaces compared to dewaxed leaves.

Custom Q&A

What is the molecular formula of Hexatriacontane?

The molecular formula of Hexatriacontane is C36H74.

What are some synonyms of Hexatriacontane?

Some synonyms of Hexatriacontane are n-Hexatriacontane, CH3-[CH2]34-CH3, and NSC-407536.

Is Hexatriacontane a natural product?

Yes, Hexatriacontane is a natural product found in Syzygium aromaticum, Torenia anagallis, and other organisms.

What is the IUPAC name of Hexatriacontane?

The IUPAC name of Hexatriacontane is hexatriacontane.

What is the InChI code for Hexatriacontane?

The InChI code for Hexatriacontane is InChI=1S/C36H74/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-36H2,1-2H3.

What is the molecular weight of Hexatriacontane?

The molecular weight of Hexatriacontane is 507.0 g/mol.

What is the boiling point of Hexatriacontane?

The boiling point of Hexatriacontane is 298.4 °C at 3 mm Hg.

What is the melting point of Hexatriacontane?

The melting point of Hexatriacontane is 75.081 °C.

How many rotatable bonds are present in Hexatriacontane?

There are 33 rotatable bonds present in Hexatriacontane.

Is Hexatriacontane a volatile compound?

No, Hexatriacontane is not a volatile compound.