Solutol hs 15

• CAS: 61909-81-7
• Catalog Number: ACM61909817
• Category: Main Products
• Molecular Weight: 0
• Molecular Formula: C20H40O4
• Synonyms: Solutol HS 15;Poly(oxy-1,2-ethanediyl), alpha-(12-hydroxy-1-oxooctadecyl)-omega-hydroxy-
• IUPAC Name: 2-hydroxyethyl12-hydroxyoctadecanoate
• SMILES: CCCCCCC(CCCCCCCCCCC(=O)OCCO)O
• InChI Key: JVKUCNQGESRUCL-UHFFFAOYSA-N

Case Study

Enhancing Oral Bioavailability and Anticancer Efficacy of Paclitaxel via a Solutol HS 15-Based Binary Mixed Micelles System

Hou, Jian, et al. International journal of pharmaceutics 512.1 (2016): 186-193.

In this study, Solutol HS 15 was used as the main component of a binary mixed-micelle system, along with Soluplus, to form an oral paclitaxel (PTX) formulation with significantly improved aqueous solubility, GI absorption and anticancer activity. At the optimized Solutol HS15: Soluplus ratio of 1:3, PTX-loaded mixed micelles (PTX-M) were small, highly drug-loaded and had a sustained release profile, lower P-glycoprotein mediated efflux, a increase in relative oral bioavailability and superior in vitro and in vivo antitumor activity compared to free PTX.
Formulation Preparation: Solutol HS15 (SOL) and Soluplus (SOLU) plus PTX were co-dissolved in ethanol. The solvent was evaporated by vacuum drying (-0.1 MPa, 45 °C) to form a thin film. Film was rehydrated in deionized water to form a clear solution. The solution was centrifuged (14,000 rpm, 10 min) and filtered (0.45 µm) to remove unincorporated drug.
Key Performance
· PTX-M exhibited a small particle size of 164.8 ± 2.0 nm with a spherical shape. Entrapment efficiency reached 98.48 ± 0.91%, with a drug loading capacity of 10.59 ± 0.09%. PTX solubility in water increased to 15.76 ± 0.15 mg/mL.
· PTX-M had a prolonged drug release. Efflux ratio was reduced by 89.72% in Caco-2 cell model, which was expected to improve intestinal absorption. Oral bioavailability of PTX-M was increased 3.68-fold than that of free PTX. IC50 values were decreased by 40.21% in MTT assays (PTX-M: 22.6 ± 2.1 μg/mL vs. PTX: 37.8 ± 1.4 μg/mL). Tumor inhibition rates in breast cancer models were improved for PTX-M (57.66%) in comparison with free PTX (41.13%). In gastrointestinal safety assays, PTX-M was biocompatible and with low toxicity.

Development of an Ophthalmic Drug Delivery System Using Solutol HS 15-Based Mixed Micelles for Curcumin

Sai, Na, et al. Molecules 25.1 (2019): 81.

This study reported the use of Solutol HS 15 as a key surfactant component in a mixed-micelle / in-situ gelling formulation designed to deliver curcumin to the eye. Formulated together with PEG-DSPE, Solutol HS 15 formed small, stable mixed micelles that substantially increased curcumin solubility and corneal penetration versus free curcumin. Those micelles were incorporated into a gellan-gum in-situ gel (Cur-MM-ISG) that produced a transparent, pseudoplastic ophthalmic system with prolonged corneal residence and no observable irritation in the reported rabbit model.
Formulation Approach
· Mixed micelle preparation (Cur-MM): Curcumin (6 mg), Solutol HS 15 (150 mg) and PEG-DSPE (100 mg) were co-dissolved in ethanol, vortexed, then solvent-evaporated under reduced pressure at 37 °C to produce a thin film. The film was hydrated with 2 mL Tris-HCl buffer (pH 7.0), stirred at 37 °C for 1 h, centrifuged (12,000 rpm, 10 min) and filtered (0.22 µm) to remove undissolved material.
· In-situ gelling system (Cur-MM-ISG): Gellan gum (0.5 g in 50 mL deionized water) was dissolved by heating at 90 °C for 2 h, cooled to room temperature, then mixed 1:1 (v/v) with the Cur-MM dispersion; mannitol was added to adjust osmotic pressure.
Key Results: Solutol HS 15 played a critical role in forming stable mixed micelles that improved curcumin's solubility and facilitated efficient corneal penetration. The in situ gelling property of gellan gum allowed the formulation to transition into a gel upon ocular administration, extending drug residence time on the corneal surface. The Cur-MM-ISG system showed excellent ocular tolerability, underscoring its potential for safe therapeutic use.

Custom Q&A

What is the molecular formula of Solutol HS 15?

The molecular formula of Solutol HS 15 is C20H40O4.

What are the synonyms of Solutol HS 15?

The synonyms of Solutol HS 15 are "2-hydroxyethyl 12-hydroxyoctadecanoate", "61909-81-7", "105109-85-1", and "6284-41-9".

What is the molecular weight of Solutol HS 15?

The molecular weight of Solutol HS 15 is 344.5 g/mol.

When was Solutol HS 15 created?

Solutol HS 15 was created on March 26, 2005.

When was Solutol HS 15 last modified?

Solutol HS 15 was last modified on October 21, 2023.

What is the IUPAC name of Solutol HS 15?

The IUPAC name of Solutol HS 15 is "2-hydroxyethyl 12-hydroxyoctadecanoate".

What is the InChI of Solutol HS 15?

The InChI of Solutol HS 15 is "InChI=1S/C20H40O4/c1-2-3-4-11-14-19(22)15-12-9-7-5-6-8-10-13-16-20(23)24-18-17-21/h19,21-22H,2-18H2,1H3".

What is the InChIKey of Solutol HS 15?

The InChIKey of Solutol HS 15 is "JVKUCNQGESRUCL-UHFFFAOYSA-N".

What is the Canonical SMILES of Solutol HS 15?

The Canonical SMILES of Solutol HS 15 is "CCCCCCC(CCCCCCCCCCC(=O)OCCO)O".

What is the CAS number of Solutol HS 15?

The CAS number of Solutol HS 15 is 6284-41-9.