TCO

TCO are a class of click chemistry reagents containing a reactive TCO group. As dienophiles, TCO can react with tetrazines by inverse electron-demand Diels-Alder (IEDDA) click reaction, which is the fastest bioorthogonal reaction found so far, and the reaction rate can reach 10000 under physiological conditions without catalysts. Due to the high reaction rate and good biocompatibility, IEDDA click reaction is widely used in labeling and bioconjugation. The structure of TCO group is shown in scheme 1. Alfa Chemistry is a leading global supplier of click chemistry reagents, with many experienced chemistry masters and PhDs. We strive to provide our customers with the highest quality TCO. If you do not find what you need, please contact us. We also offer product customization according to your detailed requirements.

Scheme 1. The structure of TCO group.

Product Name	CAS	Application
TCO-NHS ester	1191901-33-3	IEDDA Click Reaction
TCO-PNB ester	1438415-89-4	IEDDA Click Reaction
N-(2E)-TCO-L-lysine	1580501-94-5	IEDDA Click Reaction
TCO-PEG3-maleimide	1609659-01-9	IEDDA Click Reaction
TCO - amine, HCl salt	1609659-02-0	IEDDA Click Reaction
TCO-amine	1609736-43-7	IEDDA Click Reaction
TCO-PEG4-NHS ester	1613439-69-2	IEDDA Click Reaction
TCO-PEG3-amine	1800507-93-0	IEDDA Click Reaction
TCO-PEG4-DBCO	1801863-88-6	IEDDA Click Reaction
TCO-PEG4-acid	1802913-21-8	IEDDA Click Reaction
Norbornene-methyl-NHS	1986791-87-0	IEDDA Click Reaction
TCO-C3-PEG3-C3-amine	2028288-77-7	IEDDA Click Reaction
Sulfo-Cy5-TCO	2129525-69-3	IEDDA Click Reaction
TCO-PEG3-acid	2141981-86-2	IEDDA Click Reaction
TCO-PEG2-amine	2141981-87-3	IEDDA Click Reaction
TCO-PEG3-NHS ester	2141981-88-4	IEDDA Click Reaction
TCO-PEG4-biotin	2183440-30-2	IEDDA Click Reaction
TCO-PEG9-maleimide	2183440-37-9	IEDDA Click Reaction
BDP FL-PEG4-TCO	2183473-16-5	IEDDA Click Reaction
TCO-PEG12-NHS ester	2185016-39-9	IEDDA Click Reaction

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