Copper-Chelating Ligands

The efficiency of copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction strongly depends on copper ions (Cu⁺). However, Cu⁺ are easily oxidized to Cu²⁺ by residual oxygen in the solvent or air and lose their catalytic activity. In addition, Cu⁺ or Cu²⁺ exhibit strong biotoxicity, which limits many applications of CuAAC click reaction, such as targeted drug delivery and biomolecular labeling. Copper-chelating ligands are a class of substances that bind and stabilize Cu⁺, which not only maintain the high reaction rate of CuAAC click reaction, but further expand its applications in chemical biology. Alfa Chemistry is a leading global supplier of click chemistry reagents, with many experienced chemistry masters and PhDs. We strive to provide our customers with the highest quality copper-chelating ligands. If you do not find what you need, please contact us. We also offer product customization according to your detailed requirements.

Product Name	CAS	Application
BTTAA	1334179-85-9	CuAAC Click Reaction
BTTP	1341215-17-5	CuAAC Click Reaction
BTTES	2101505-88-6	CuAAC Click Reaction
TBTA	510758-28-8	CuAAC Click Reaction
THPTA	760952-88-3	CuAAC Click Reaction