Sulfur (VI) Fluorides

Sulfur (VI) fluorides are a class of click chemistry reagents containing S-F chemical bonds, which result in their unique properties such as hydrolytic stability and resistance to reduction. Initially, as covalent protein modifiers, they were applied to proteomics, protease inhibitors, and chemical probes. Until 2014, sulfur-fluoride exchange (SuFEx) click reaction were proposed by Sharpless and coworkers, the application of sulfur (VI) fluorides really took off. In contrast to other sulfur(VI) halides, sulfur(VI) fluorides react exclusively at the sulfur atom in the presence of nucleophiles primarily through a nucleophilic addition/elimination mechanism. Common sulfur (VI) fluorides include sulfonyl fluorides (RSO₂F), fluorosulfates (ROSO₂F), and sulfamoyl fluorides (R₂NSO₂F), which have important applications in chemical biology to polymers. Alfa Chemistry is a leading global supplier of click chemistry reagents, with many experienced chemistry masters and PhDs. We strive to provide our customers with the highest quality sulfur (VI) fluorides. If you do not find what you need, please contact us. We also offer product customization according to your detailed requirements.

Product Name	CAS	Application
2,5-Dibromobenzenesulfonyl fluoride	1092278-47-1	SuFEx Click Reaction
Ethyl 2-(((trifluoromethyl)sulfonyl)oxy)cyclopent-1-enecarboxylate	122539-74-6	SuFEx Click Reaction
Ammonium fluorosulfate	13446-08-7	SuFEx Click Reaction
Sulfamideoic fluoride	14986-54-0	SuFEx Click Reaction
Cyclopent-1-en-1-yl trifluoromethanesulfonate	28075-49-2	SuFEx Click Reaction
Dimethylsulfamoyl fluoride	354-44-9	SuFEx Click Reaction
2-(Trifluoromethylsulfonyloxy)-1-cyclopentene-1-carboxylic acid methyl ester	65832-21-5	SuFEx Click Reaction
Cyclopropylsulfonyl fluoride	822-49-1	SuFEx Click Reaction