Terminal Alkynes

Terminal alkynes are alkynes in whose molecules there are at least one hydrogen atom bonded to a triply bonded carbon atom (Scheme 1), and propyne is the simplest and most typical terminal alkyne. The hydrogen atom bonded to the terminal alkyne carbon shows higher acidity than the hydrogen atoms bonded to the carbons of an alkene or alkane, and the pKa value is about 25. Because of the relatively high acidity, terminal alkynes can be deprotonated by appropriate strong bases, such as NaH and NaNH₂. As one of the main reactants of the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), thiol-yne and spontaneous amino-yne click reactions, terminal alkynes promote the application of these click reactions in many fields, such as medicine and biology. Alfa Chemistry is a leading global supplier of click chemistry reagents, with many experienced chemistry masters and PhDs. We strive to provide our customers with the highest quality terminal alkynes. If you do not find what you need, please contact us. We also offer product customization according to your detailed requirements.

Scheme 1. Schematic diagram of terminal alkynes.

Product Name	CAS	Application
Biotin-PEG4-amide-alkyne	1006592-45-5	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
10-Undecynoyl-OSu	1006592-57-9	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Propargyl-C8-amido-PEG2-NHS ester	1006592-59-1	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Biotin-PEG2-C4-alkyne	1011268-28-2	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
7-Octynoic acid	10297-09-3	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Propargyl-PEG6-Ms	1036204-62-2	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Propargyl-PEG3-phosphonic acid diethyl ester	1052678-30-4	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
m-PEG5-propyne	1101668-41-0	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
O-Propargyl-D-tyrosine	1170674-20-0	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Propargyl-PEG1-THP	119096-95-6	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
1-Azido-3,6,9,12-tetraoxapentadec-14-yne	1192590-91-2	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Azido-PEG8-propargyl	1196733-06-8	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Propargyl-NH-PEG3-C2-NHS ester	1214319-94-4	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Cyanine5 alkyne	1223357-57-0	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
TAMRA-PEG4-alkyne	1225057-68-0	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
(S)-2-Amino-2-methylpent-4-ynoic acid	1231709-27-5	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
3-[2-(2-Iodoethoxy)-ethoxy]-propyne	1234387-33-7	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
3-(2-(2-Azidoethoxy)ethoxy)prop-1-yne	1245006-63-6	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Folate-PEG3-alkyne	1245285-73-7	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Biotin-PEG4-SS-alkyne	1260247-54-8	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction

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