SuFEx Click Reaction

The sulfur (VI) fluoride exchange (SuFEx) click reaction was developed by Sharpless and co-workers in 2014, which relies on readily available sulfuryl fluoride (SO₂F₂) and ethenesulfonyl fluoride (ESF) to build diverse chemical structures bearing the S(VI)-F motif, such as -OSO2F (fluorosulfate) and -SO₂F (sulfonyl fluoride)^[1]. Usually, this reaction requires the assistance of "H⁺" or "R₃Si⁺"^[2]. With modifications and improvements, SuFEx click reaction allows the formerly undervalued sulfate bond to be utilized as a bridge connecting many molecules. The schematic diagram of the SuFEx click reaction is shown in scheme 1^[3].

Scheme 1. Schematic diagram of the SuFEx click reaction.

Advantages

SuFEx click reaction has attracted great interest in various fields because of its advantages. These advantages include, but are not limited to, the following.

Applications

A large number of studies have shown that SuFEx click reaction has significant value in many fields. For example, SuFEx click reaction can be used to add functional groups to pharmaceutical active ingredients to modify and improve their properties and functions. In addition, SuFEx click reaction has been successfully applied to polymer chemistry with the efficient formation of polymers derived from sulfonyl fluorides, fluoro-sulfates, etc.

What Can We Do?

As a leading customer-focused company, Alfa Chemistry has experienced experts and professional R & D laboratories. For many years, we have been focusing on reagent development and potential application exploration of the SuFEx click reaction. If you have questions about the SuFEx click reaction, please contact us. We will draw upon our wide range of advantages and high-quality products to create customized, scalable, efficient solutions for your research.

References

1. Liu, Z.; et al. Novel approaches to access arylfluorosulfates and sulfamoyl fluorides based on sulfur (VI) fluoride exchange. Current Protocols in Chemical Biology.
2. Chao, Y.; et al. Sulfur-phenolate exchange: SuFEx-derived dynamic covalent reactions and degradation of SuFEx polymers. Angewandte Chemie International Edition. 2022, 61: 1-7.
3. Fattah, T.A.; et al. Recent advances towards sulfur (VI) fluoride exchange (SuFEx) click chemistry. Journal of Fluorine Chemistry. 2018, 213: 87-112.