L-Norleucine

• CAS: 327-57-1
• Catalog Number: ACM327571
• Category: Inhibitors
• Molecular Weight: 131.17
• Molecular Formula: C6H13NO2
• Description: L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
• Synonyms: Alpha-aminocaproic acid
• IUPAC Name: 3-[(2S)-1-Methylpyrrolidin-2-yl]pyridine
• SMILES: CN1CCCC1C2=CN=CC=C2
• InChI: InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
• InChI Key: SNICXCGAKADSCV-JTQLQIEISA-N
• Boiling Point: 234 °C/760 mmHg
• Melting Point: >300 °C(lit.)
• Flash Point: 275 °C
• Density: 1.1720 g/cm³
• Solubility: Slightly soluble in ligroin
• Appearance: White to off-white crystalline powder
• Storage: Sealed in dry, room temperature
• Complexity: 147
• Exact Mass: 162.115698455
• Isomeric SMILES: CN1CCC[C@H]1C2=CN=CC=C2
• Monoisotopic Mass: 162.115698455
• pKa: 2.335(at 25 °C)
• Topological Polar Surface Area: 16.1 Ų

Synthetic Use

Downstream Synthesis Route 1

• 1070-19-5
• 327-57-1

• 6404-28-0

Reference: [1] Phytochemistry, 2003, vol. 62, # 7, p. 1133 - 1140

Downstream Synthesis Route 2

• 327-57-1
• 108-24-7

• 15891-49-3

Reference: [1] Journal of the American Chemical Society, 1956, vol. 78, p. 4636,4642

Downstream Synthesis Route 3

• 327-57-1
• 24424-99-5

• 6404-28-0

Reference: [1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 21, p. 6891 - 6899
[2] Bioorganic and medicinal chemistry letters, 2004, vol. 14, # 1, p. 275 - 278

Downstream Synthesis Route 4

• 67-56-1
• 327-57-1

• 21754-55-2

Reference: [1]Flowers; Reith
[Biochemical Journal, 1953, vol. 53, p. 657,658]
[2]Mazur,R.H. et al.
[Journal of Medicinal Chemistry, 1973, vol. 16, p. 1284 - 1287]
Braconnier, M.F.; Braekman, J.C.; Daloze, D.
[Bulletin des Societes Chimiques Belges, 1985, vol. 94, # 8, p. 605 - 614]
[3]Olsson, Sandra; Schäfer, Clara; Blom, Magnus; Gogoll, Adolf
[ChemPlusChem, 2018, vol. 83, # 12, p. 1169 - 1178]

Downstream Synthesis Route 5

• 327-57-1

• 70267-26-4

Reference: [1]Focella; Bizzarro; Exon
[Synthetic Communications, 1991, vol. 21, # 21, p. 2165 - 2170]

Downstream Synthesis Route 6

• 327-57-1

• 449806-68-2

Reference: [1]Abderhalden; Heyns
[Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1933, vol. 214, p. 262,266]
[2]Current Patent Assignee: TAIMED BIOLOGICS, INC. - US2002/151546, 2002, A1

* For details of the synthesis route, please refer to the original source to ensure accuracy.