α-Lipoic acid

• CAS: 1077-28-7
• Catalog Number: ACM1077287-1
• Category: Inhibitors
• Molecular Weight: 206.33
• Molecular Formula: C8H14O2S2
• Description: α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.
• Synonyms: DL-6-Thioctic acid
• IUPAC Name: 5-(Dithiolan-3-yl)pentanoic acid
• Canonical SMILES: C1CSSC1CCCCC(=O)O
• InChI: InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
• InChI Key: AGBQKNBQESQNJD-UHFFFAOYSA-N
• Boiling Point: 160-165 °C(lit.)
• Melting Point: 60-62 °C
• Flash Point: 160-165 °C
• Density: 1.2888 g/cm³
• Solubility: Soluble in methanol, ethanol, diethyl ether, chloroform
• Appearance: Yellow powder
• Storage: 2-8 °C
• Complexity: 150
• Exact Mass: 206.04352203
• Monoisotopic Mass: 206.04352203
• pKa: 4.75±0.10(Predicted)
• Refractive Index: 1.5200
• Topological Polar Surface Area: 87.9 Ų