Loratadine

• CAS: 79794-75-5
• Catalog Number: ACM79794755
• Category: Inhibitors
• Molecular Weight: 382.88
• Molecular Formula: C22H23ClN2O2
• Description: Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
• Synonyms: Claritin
• IUPAC Name: Ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
• Canonical SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
• InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
• InChI Key: JCCNYMKQOSZNPW-UHFFFAOYSA-N
• Boiling Point: 531.3±50.0 °C
• Melting Point: 134-136 °C
• Flash Point: 275.1 °C
• Density: 1.261±0.06 g/cm³
• Appearance: White powder
• Storage: 2-8 °C
• Complexity: 569
• Exact Mass: 382.1448057
• Monoisotopic Mass: 382.1448057
• pKa: 4.27±0.20(Predicted)
• Topological Polar Surface Area: 42.4 Ų