CDK2 degrader 1

• CAS: 3036604-59-5
• Catalog Number: ACM-MG-3036604595
• Category: Molecular Glues
• Molecular Weight: 447.47
• Molecular Formula: C23H27F2N3O4
• Description: CDK2 degrader 1 is a selective CDK2 molecular glue degrader with a Dmax (CDK2) of > 80% and a Ki (CRBN) > 1 μM.
• Synonyms: BDBM765776
• IUPAC Name: [(1R,2R,4S)-2-bicyclo[2.2.1]heptanyl]methyl N-[1-[4-(2,6-dioxopiperidin-3-yl)-3,5-difluorophenyl]azetidin-3-yl]carbamate
• SMILES: [H][C@](C1)(CC2)C[C@]2([H])[C@@H]1COC(NC3CN(C4=CC(F)=C(C5C(NC(CC5)=O)=O)C(F)=C4)C3)=O
• InChI: InChI=1S/C23H27F2N3O4/c24-18-7-16(8-19(25)21(18)17-3-4-20(29)27-22(17)30)28-9-15(10-28)26-23(31)32-11-14-6-12-1-2-13(14)5-12/h7-8,12-15,17H,1-6,9-11H2,(H,26,31)(H,27,29,30)/t12-,13+,14-,17?/m0/s1
• InChI Key: KUTYUVCSHRYCRH-QYCFJQJSSA-N
• Appearance: White to off-white solid
• Shipping: Room temperature; may vary elsewhere.
• Storage Conditions: 4 °C, protect from light, stored under nitrogen