Terminal Alkynes

Terminal alkynes are alkynes in whose molecules there are at least one hydrogen atom bonded to a triply bonded carbon atom (Scheme 1), and propyne is the simplest and most typical terminal alkyne. The hydrogen atom bonded to the terminal alkyne carbon shows higher acidity than the hydrogen atoms bonded to the carbons of an alkene or alkane, and the pKa value is about 25. Because of the relatively high acidity, terminal alkynes can be deprotonated by appropriate strong bases, such as NaH and NaNH₂. As one of the main reactants of the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), thiol-yne and spontaneous amino-yne click reactions, terminal alkynes promote the application of these click reactions in many fields, such as medicine and biology. Alfa Chemistry is a leading global supplier of click chemistry reagents, with many experienced chemistry masters and PhDs. We strive to provide our customers with the highest quality terminal alkynes. If you do not find what you need, please contact us. We also offer product customization according to your detailed requirements.

Scheme 1. Schematic diagram of terminal alkynes.

Product Name	CAS	Application
Bezisterim	1001100-69-1	CuAAC Click Reaction
FT011	1001288-58-9	CuAAC Click Reaction
Tirasemtiv	1005491-05-3	CuAAC Click Reaction
Biotin-PEG4-amide-alkyne	1006592-45-5	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
10-Undecynoyl-OSu	1006592-57-9	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Propargyl-C8-amido-PEG2-NHS ester	1006592-59-1	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
Fmoc-N-propargyl-MPBA	1009362-00-8	CuAAC Click Reaction
CY3-YNE	1010386-62-5	CuAAC Click Reaction
4-Hydroxynonenal alkyne	1011268-23-7
Biotin-PEG2-C4-alkyne	1011268-28-2	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
CUDC-101	1012054-59-9	CuAAC Click Reaction
Sodium 4-pentynoate	101917-30-0	CuAAC Click Reaction
7-Octynoic acid	10297-09-3	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
CL-197	1030595-07-3	CuAAC Click Reaction
Flumioxazin	103361-09-7	CuAAC Click Reaction
γ-Acetylenic GABA hydrochloride	103451-26-9	CuAAC Click Reaction
Erlotinib-d6	1034651-23-4	CuAAC Click Reaction
Propargyl-PEG6-Ms	1036204-62-2	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction
NITD008	1044589-82-3	CuAAC Click Reaction
Propargyl-PEG3-phosphonic acid diethyl ester	1052678-30-4	CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction

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