CAS
83471-50-5 Purity
96%
83471-50-5 Purity
96%
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Gastric Mucin
CAS
84082-64-4
Catalog Number
ACM84082644
Category
Main Products
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Specification
Synonyms
mucin from porcine stomach
Appearance
Off White to Light Brown
Powder
Powder
How Gastric Gland Mucin Functions to Prevent Gastric Cancer Development in Mice Models
Karasawa, Fumitoshi, et al. The Journal of clinical investigation 122.3 (2012): 923-934.
The gastric glands located in the lower gastric mucosa produce mucin which features unique O-linked oligosaccharides (O-glycans) ending with α1,4-linked N-acetylglucosamine residues (αGlcNAc). The human enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) essential for O-glycan biosynthesis has been identified earlier while its αGlcNAc component demonstrated inhibitory effects on Helicobacter pylori in vitro. Researchers applied A4gnt-/- mice to study the in vivo effects of α4GnT. αGlcNAc was completely absent from the gastric gland mucin of the mice used in the study. Gastric adenocarcinoma developed in mutant mice via hyperplasia-dysplasia-carcinoma progression without any influence from H. pylori infection.
Key findings
Quantitative RT-PCR and microarray analyses identified increased expression of genes corresponding to inflammatory chemokine ligands as well as proinflammatory cytokines and growth factors including Ccl2, Il-11 and Hgf in the gastric mucosa from A4gnt-/- mice. αGlcNAc levels showed marked decreases in human gastric adenocarcinoma and adenoma samples.
The absence of αGlcNAc triggers gastric tumor development through inflammation-related pathways in living organisms while αGlcNAc-terminated gastric mucin protects against gastric cancer by both preventing H. pylori infection and reducing inflammation that promotes tumors.
Study on the Interaction Between Porcine Gastric Mucin and Water-Soluble Polymers
Albarkah, Yasser A., et al. Macromolecular Bioscience 15.11 (2015): 1546-1553.
Mucin is a complex, colloidal system characterized by polydispersity that can undergo disaggregation and aggregation through processes like sonication or filtration. This study focuses on the structural characteristics of porcine gastric mucin (PGM) in aqueous solutions and its interactions with various water-soluble polymers, including poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), poly(ethylene oxide) (PEO), and poly(ethylene glycol) (PEG).
Key Findings
Monodisperse samples can be effectively produced via sonication. Mucin reveals specific interactions with PAA (450 kDa) and PMAA (100 kDa), prompting the aggregation of its particles and the creation of larger agglomerates. These interactions are exothermic and are attributed to hydrogen bonding between the carboxylic groups of the polymers and the hydroxyl groups in the oligosaccharide residues of mucin.
Sonicated samples with smaller mucin particles and larger surface areas had stronger interactions with PAA (450 kDa) and PMAA (100 kDa). The interactions between mucin and PAA were due to hydrogen bonding and the addition of urea had a large effect on the interaction. At high concentrations of urea, the interaction was completely prevented. Low molecular weight PAA (2 kDa), as well as PEG (10 kDa) and PEO (1,000 kDa) did not have any interaction with mucin.
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