Blueberry extract

• CAS: 84082-34-8
• Catalog Number: ACM84082348
• Category: Main Products
• Molecular Weight: 611.53
• Molecular Formula: C₂₇H₃₁O₁₆
• Synonyms: BILBERRY EXTRACT;Vaccinium myrtillus, ext.;Bilberry Seed Oil;Blue Tocal Bilberry Seed Oil;Vaccinium Myrtillus;VACCINIUM MYRTILLUS EXTRACT;BILBERRY EXTRACT 25%;BILBERRYFRUITEXTRACT
• IUPAC Name: Bilberry Extract
• Exact Mass: 594.13700

Case Study

Evaluation of Antimicrobial, Antiadhesion and Antibiofilm Activities of Blueberry Extract

Silva, Sara, et al. Journal of applied microbiology, 2016, 121(3), 693-703.

The research investigated how blueberry extract affects the growth and biofilm production of multiple pathogens and multidrug-resistant bacteria.
Methods
Researchers extracted blueberry pulp by employing an acidified ethanol solution before purifying the extract through solid phase extraction. Antimicrobial properties were evaluated against reference strains alongside multidrug-resistant clinical isolates from Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Acinetobacter baumannii, and Staphylococcus aureus. Then measured microbial growth by optical density and assessed adhesion and biofilm formation through the standard crystal violet staining method.
Key Findings
· Anthocyanins were found to be the predominant phenolic compounds in the extract at 184.7 µg/mg while neochlorogenic acid was present at 32.1 µg/mg as the only other phenolic compound detected.
· The blueberry extract showed limited effectiveness in stopping Staphylococcus aureus and E. coli growth but achieved significant reductions in biofilm formation and bacterial adhesion among all tested microorganisms.
· The blueberry extract presents as a potential natural antimicrobial agent since it can interrupt microbial growth and surface adhesion while Staphylococcus aureus shows the highest sensitivity.

Study on the Effect of Blueberry Extract on Extending the Lifespan of Fruit Flies

Peng, Cheng, et al. Experimental gerontology, 2012, 47(2), 170-178.

Blueberry exhibits higher antioxidant capacity than most fruits and vegetables. This study investigated how blueberry extracts can prolong fruit fly lifespan.
Key Findings
· A diet containing 5 mg/ml blueberry extract significantly increased mean fly lifespan by 10%. This was associated with upregulated expression of superoxide dismutase (SOD), catalase (CAT), and Rpn11 genes, and downregulated expression of the Methuselah (MTH) gene.
· Under intense H2O2 or Paraquat stress, lifespan extension only occurred in wild-type (Oregon-R) flies, not in SODn108 or Catn1 mutants. Chronic Paraquat exposure reduced maximum survival from 73 to 35 days and decreased climbing ability by 60%. However, the blueberry extract diet significantly increased survival rates and partially restored climbing ability, coinciding with upregulated SOD, CAT, and Rpn11 expression.
· Food intake variations between control and blueberry-supplemented diets were ruled out as the cause of observed effects according to gustatory assay results. Therefore, the lifespan-extending effect of blueberry extract is at least partially linked to its interaction with MTH, Rpn11, and the endogenous antioxidant enzymes SOD and CAT.