CAS
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STING Degrader 2
Catalog Number
ACM-MG-00086
Category
Molecular Glues
Molecular Weight
504.40
Molecular Formula
C26H24N4O7
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Specification
Description
STING Degrader 2 is a molecular glue that covalently binds both STING and RNF126 E3 ligase leading to proteasomal degradation. It displayed sustained STING degradation with faster onset and at lower concentration when compared to the STING PROTAC SP23.
Synonyms
(E)-N-(4-(4-(4-(4-methoxyphenyl)-4-oxobut-2-enoyl)piperazin-1-yl)phenyl)-5-nitrofuran-2-carboxamide
Solubility
Soluble in DMSO (>25 mg/ml)
Appearance
Orange solid
Shipping
Room temperature
Stability
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20 °C for up to 3 months.
Storage Conditions
Store at -20 °C
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