STING Degrader 1

• CAS: 2762552-74-7
• Catalog Number: ACM-MG-2762552747
• Category: Molecular Glues
• Molecular Weight: 699.68
• Molecular Formula: C34H33N7O10
• Description: STING degrader 1 is a CRBN-based PROTAC degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the Stimulator of Interferon Genes (STING).
• Synonyms: (E)-N-[6-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]-N'-[4-[(5-nitrofuran-2-carbonyl)amino]phenyl]but-2-enediamide; SP23
• IUPAC Name: (E)-N-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]-N'-[4-[(5-nitrofuran-2-carbonyl)amino]phenyl]but-2-enediamide
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCNC(=O)/C=C/C(=O)NC4=CC=C(C=C4)NC(=O)C5=CC=C(O5)[N+](=O)[O-]
• InChI: InChI=1S/C34H33N7O10/c42-26(15-16-27(43)37-20-8-10-21(11-9-20)38-32(46)25-13-17-29(51-25)41(49)50)36-19-4-2-1-3-18-35-23-7-5-6-22-30(23)34(48)40(33(22)47)24-12-14-28(44)39-31(24)45/h5-11,13,15-17,24,35H,1-4,12,14,18-19H2,(H,36,42)(H,37,43)(H,38,46)(H,39,44,45)/b16-15+
• InChI Key: TXNQXRGOKABDOB-FOCLMDBBSA-N
• Solubility: Soluble in DMSO (25 mg/ml)
• Appearance: Yellow to beige solid
• Shipping: Room temperature
• Stability: Stable for up to 2 years when stored as supplied at -20 °C. Solutions in DMSO may be stored at -20 °C for up to 2 months.
• Storage Conditions: Store at -20 °C