Poly(propylene glycol) dimethacrylate

• CAS: 25852-49-7
• Catalog Number: ACM25852497
• Category: Main Products
• Molecular Weight: 162.18
• Molecular Formula: C7H14O4
• Synonyms: 2-methylprop-2-enoic acid;propane-1,3-diol
• Flash Point: 113 °C
• Appearance: Colorless to Faint Yellow Liquid

Case Study

Enhancing Mechanical Properties of Bone Regeneration Hydrogels with Poly(Propylene Glycol) Dimethacrylate

Killion, John A., et al. Journal of Materials Science 47.18 (2012): 6577-6585.

Poly(propylene glycol) dimethacrylate (PPGDMA) was used together with polyethylene glycol dimethacrylate (PEGDMA) to produce photocured, highly crosslinked hydrogels. Varying the PEGDMA/PPGDMA ratio and PEGDMA molecular weight allowed controlled modulation of network formation, swelling, glass transition and-critically-mechanical properties relevant to low load-bearing bone-repair applications. Incorporation of PEGDMA into PPGDMA matrices increased compressive stiffness; for example, with PEGDMA-400 the Young's modulus in unconfined compression was reported in the range 6.62 ± 0.31 MPa to 8.08 ± 0.81 MPa for compositions tested.
Formulation & Photopolymerisation
PPGDMA and PEGDMA (various molecular weights and ratios) were blended until homogeneous (magnetic stirring ~1 h). Solutions were dispensed into silicone moulds with disc impressions (23 mm diameter × 2.2 mm thickness). Photopolymerisation used a UV chamber (315-400 nm spectral range, average intensity 10-13.5 mW/cm2). Gelation occurred within a 10-minute exposure. This free-radical UV cure produced highly crosslinked hydrogels suitable for mechanical and rheological testing.

Enhancing Dental Composite Performance through Poly(propylene glycol) Dimethacrylate Formulation

Walters, Nick J., et al. Dental materials 32.2 (2016): 264-277.

In this work, poly(propylene glycol) dimethacrylate (PPGDMA) used as the diluent monomer in light-cured dental composites improves polymerisation conversion and depth of cure compared with the conventional diluent triethylene glycol dimethacrylate (TEGDMA), without increasing volumetric shrinkage or impairing mechanical performance. When paired with urethane dimethacrylate (UDMA) as the bulk monomer, formulations showed especially good conversion, depth of cure and biaxial flexural strength.
Materials & Formulation: 4 experimental composites were formulated using a microhybrid filler system (10% 40nm fumed silica, 90% silane-treated glass particles) with different monomer combinations: UP (UDMA + PPGDMA), UT (UDMA + TEGDMA), BP (Bis-GMA + PPGDMA), and BT (Bis-GMA + TEGDMA). All systems had a 3.5: 1 bulk:diluent molar ratio, and a consistent photoinitiator system (CQ/DMAEMA). Composites were mixed using centrifugal planetary mixing with fixed powder-to-liquid ratio (40 vol%).
Key Findings
· UDMA vs Bis-GMA: UDMA-based composites showed significantly higher degree of conversion, deeper cure and improved biaxial flexural strength compared with Bis-GMA systems, while not increasing volumetric shrinkage.
· PPGDMA vs TEGDMA: Replacing TEGDMA with PPGDMA improved conversion and depth of cure, again without deleterious effects on shrinkage. Mechanical properties were maintained or improved in the UDMA+PPGDMA systems.
· PPGDMA gave a more favourable signal in the resazurin assay compared with TEGDMA, but WST-8 and MTS assays did not corroborate improved cytocompatibility - demonstrating assay-dependent outcomes.