M47

• CAS: 890808-56-7
• Catalog Number: ACM-MG-890808567
• Category: Molecular Glues
• Molecular Weight: 471.93
• Molecular Formula: C28H22ClNO4
• Description: M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus.
• Synonyms: 11-(4-chlorophenyl)-4-(2,3-dihydro-1H-indole-1-carbonyl)-3,11-dimethyl-5,10-dioxatricyclo(7.4.0.0,2,6)trideca-1,3,6,8-tetraen-13-one
• IUPAC Name: 7-(4-chlorophenyl)-2-(2,3-dihydroindole-1-carbonyl)-1,7-dimethyl-8H-furo[3,2-f]chromen-9-one
• SMILES: O=C(N1C2=C(CC1)C=CC=C2)C(OC3=CC=C4OC(C)(C5)C6=CC=C(C=C6)Cl)=C(C)C3=C4C5=O
• InChI: InChI=1S/C28H22ClNO4/c1-16-24-22(33-26(16)27(32)30-14-13-17-5-3-4-6-20(17)30)11-12-23-25(24)21(31)15-28(2,34-23)18-7-9-19(29)10-8-18/h3-12H,13-15H2,1-2H3
• InChI Key: HUWLQJUHXIKAIW-UHFFFAOYSA-N
• Appearance: Off-white to light yellow solid
• Shipping: Room temperature; may vary elsewhere.
• Storage Conditions: Store at -20 °C