CAS
3093763-27-7 Purity
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3093763-27-7 Purity
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Galeterone
CAS
851983-85-2
Catalog Number
ACM-MG-851983852
Category
Molecular Glues
Molecular Weight
388.55
Molecular Formula
C26H32N2O
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Specification
Description
Galeterone (TOK-001) is a potent, orally active molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2.
Synonyms
TOK-001; VN-124-1
IUPAC Name
(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
SMILES
C[C@@]12C(N3C=NC4=CC=CC=C34)=CC[C@]1([C@@]5(CC=C6[C@@](C)([C@]5(CC2)[H])CC[C@@H](C6)O)[H])[H]
InChI
InChI=1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1
InChI Key
PAFKTGFSEFKSQG-PAASFTFBSA-N
Appearance
White to off-white solid
Shipping
Room temperature; may vary elsewhere.
Storage Conditions
Store at -20 °C
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