CAS
3050683-03-6 Purity
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3050683-03-6 Purity
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JP-2-196 (TFA)
CAS
3065021-33-9
Catalog Number
ACM-MG-3065021339
Category
Molecular Glues
Molecular Weight
388.34
Molecular Formula
C17H19F3N2O5
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Specification
Description
JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders.
Synonyms
(2E)-1-(4-methoxyphenyl)-4-(piperazin-1-yl)but-2-ene-1,4-dione, trifluoroacetic acid
IUPAC Name
(E)-1-(4-methoxyphenyl)-4-piperazin-1-ylbut-2-ene-1,4-dione;2,2,2-trifluoroacetic acid
SMILES
OC(C(F)(F)F)=O.O=C(N1CCNCC1)/C=C/C(C2=CC=C(C=C2)OC)=O
InChI
InChI=1S/C15H18N2O3.C2HF3O2/c1-20-13-4-2-12(3-5-13)14(18)6-7-15(19)17-10-8-16-9-11-17;3-2(4,5)1(6)7/h2-7,16H,8-11H2,1H3;(H,6,7)/b7-6+;
InChI Key
FXBSOXIEMBFWQY-UHDJGPCESA-N
Appearance
Light yellow to yellow solid
Shipping
Room temperature; may vary elsewhere.
Storage Conditions
Store at room temperature, keep dry and cool
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