506-30-9 Purity
99%+
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This study explores the cardioprotective role of inositol, administered as an 80:1 mixture of myo-inositol and d-chiro-inositol, against lithium-induced cardiac toxicity in C57BL6 mice. Mice were divided into four groups (n=10 per group): a lithium-only group (Li₂CO₃, 8 weeks), a lithium followed by inositol supplementation group (Li_INOdelayed, 8+4 weeks), a group receiving lithium and inositol concurrently for 12 weeks (Li+INO), and an untreated control group. Inositol was delivered via drinking water. Cardiac structure and function were evaluated using echocardiography, electrocardiography, and histopathological analysis. Ventricular tissue was further analyzed for cardiomyocyte size, ERK1/2 signaling, Kv1.5 potassium channel expression, and BNP transcription levels. Inositol effectively attenuated lithium-induced systolic dysfunction, hypertrophy, and arrhythmogenic susceptibility. Notably, concurrent supplementation prevented cardiac damage, while delayed administration reversed established impairments. Inositol's effects were linked to normalization of hypertrophy markers and suppression of ERK1/2 activation. Additionally, inositol alleviated lithium-related injuries in the liver and kidney.
This study investigated the application of inositol in high-lipid diets (16% crude lipid, 51% crude protein) to improve growth performance and intestinal health in juvenile hybrid grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus). Six isonitrogenous and isolipidic diets were formulated with graded levels of inositol: 0% (control), 0.04%, 0.08%, 0.16%, 0.32%, and 0.64%. Fish with an initial average weight of 6.76 ± 0.34 g were fed these diets for 8 weeks. Specific growth rate significantly improved in the 0.08-0.64% inositol-supplemented groups (P > 0.05). Digestive enzyme activities-particularly amylase, lipase, and trypsin-increased with higher inositol concentrations, with statistically significant enhancements observed in all inositol-treated groups (P < 0.05). Histological analysis revealed that inositol supplementation significantly increased plica width, muscularis thickness, and goblet cell numbers (P < 0.05), despite no changes in plica height. Intestinal microbiota analysis showed a higher OTU count and Simpson diversity index in the 0.08% inositol group. Dominant microbial taxa included Proteobacteria and Vibrionaceae. These findings demonstrate that dietary inositol, particularly at 0.08-0.64%, effectively enhances digestive enzyme activity, intestinal morphology, microbial diversity, and growth in hybrid grouper, making it a valuable additive in high-lipid aquafeeds.
The CAS number of Inositol is 87-89-8.
Some synonyms for Inositol are myo-Inositol and cis-1,2,3,5-trans-4,6-Cyclohexanehexol.
The molecular formula of Inositol is C6H12O6.
The molecular weight of Inositol is 180.16.
The purity of Inositol is 98%.
The physical state of Inositol is a solid.
Inositol is used as a dispersing agent and emulsifying agent, as well as an intermediate in organic synthesis.
The melting point of Inositol is 222-227 °C.
The density of Inositol is 1.75g/ml.
The pH of Inositol is 5-7 in a 100g/l solution at 20 °C.
Reference: [1]Wieland; Wishart
[Chemische Berichte, 1914, vol. 47, p. 2084]
[2]Anderson; Wallis
[Journal of the American Chemical Society, 1948, vol. 70, p. 2931,2933]
Angyal; McHugh
[Journal of the Chemical Society, 1957, p. 3682,3688]
[3]Kuhn; Quadbeck; Roehm
[Justus Liebigs Annalen der Chemie, 1949, vol. 565, p. 1,5]
Reference: [1] Journal of the American Chemical Society, 1958, vol. 80, p. 2022
Reference: [1] Helvetica Chimica Acta, 1936, vol. 19, p. 1333,1341[2] Helvetica Chimica Acta, 1946, vol. 29, p. 1991,1996, 1997
[3] Journal of the American Chemical Society, 1942, vol. 64, p. 67
[4] Journal of the American Chemical Society, 1930, vol. 52, p. 2483,2485, 2492
[5] Journal of the American Chemical Society, 1940, vol. 62, p. 2397,2398
Reference: [1]Helvetica Chimica Acta,1936,vol. 19,p. 1333,1341
Helvetica Chimica Acta,1946,vol. 29,p. 1991,1996, 1997
Reference: [1]Journal of the American Chemical Society,1958,vol. 80,p. 2022
* For details of the synthesis route, please refer to the original source to ensure accuracy.