Chromium nicotinate

• CAS: 64452-96-6
• Catalog Number: ACM64452966
• Category: Main Products
• Molecular Weight: 418.3
• Molecular Formula: Cr(C₆H₄NO₂)₃
• Synonyms: chromium: pyridine-3-carboxylate;Chromium nicotinate;3-pyridinecarboxylate, chromium salt;chromium(3+) tripyridine-3-carboxylate
• IUPAC Name: chromium(3+);pyridine-3-carboxylate
• Canonical SMILES: C1=CC(=CN=C1)C(=O)[O-].C1=CC(=CN=C1)C(=O)[O-].C1=CC(=CN=C1)C(=O)[O-].[Cr+3]
• InChI Key: MSPQQAUTCRWLGR-UHFFFAOYSA-K
• Boiling Point: 292.5ºC at 760 mmHg
• Exact Mass: 418.01300

Case Study

Molecular Docking Analysis of Chromium(III) Nicotinate with Protein Tyrosine Phosphatase for Antidiabetic Supplement Development

Ambarwati, Yuli, et al. Jurnal Kimia Valensi 3.2 (2017).

This study examined the molecular interaction between chromium(III) nicotinate complexes and human Protein Tyrosine Phosphatase (PTP), a key enzyme target in type 2 diabetes. Using computational docking methods, the study evaluates the potential of chromium nicotinate-a widely used antidiabetic supplement-to act as a regulatory agent through targeted enzyme inhibition.
Two coordination forms of chromium(III) nicotinate were investigated, including O-coordinated trans and cis isomers (trans-[Cr(O-nic)2(OH-)(H2O)3] and cis-[Cr(O-nic)2(OH-)(H2O)3]), and N-coordinated trans isomer: trans-[Cr(N-nic)2(OH-)(H2O)3].
Key Findings
· trans-[Cr(O-nic)2(OH-)(H2O)3] exhibited the strongest binding affinity with an interaction energy of -6.5 kcal/mol. It formed interactions with residues Leu13, Gly14, Cys17, Arg18, Trp49, and Asn50.
· cis-[Cr(O-nic)2(OH-)(H2O)3] showed slightly weaker binding (-6.1 kcal/mol), interacting with Ile16, Trp49, Asn50, Arg53, Asp56, and Tyr131.
· trans-[Cr(N-nic)2(OH-)(H2O)3] also demonstrated significant binding (-6.5 kcal/mol), engaging Leu13, Ser47, Trp49, Asn50, and Tyr131.
· The computational analysis confirmed that hydrogen bonding serves as the primary interaction mechanism between the chromium complexes and PTP. The trans O-coordinated complex formed seven hydrogen bonds and one sulfide bond (2.5 Å distance), indicating stable and specific binding.

Evaluating the Safety Profile of Chromium Nicotinate in Human Mammary Epithelial Cells

Dębski, Bogdan, et al. Probl. Hig. Epidemiol 97 (2016): 95-99.

Chromium(III) is an essential trace element involved in macronutrient metabolism, and its deficiency has been linked to metabolic disorders such as type 2 diabetes. Among dietary supplements, chromium is commonly available as chromium picolinate, chromium nicotinate, or chromium chloride. This case study focused on assessing and comparing the impact of chromium nicotinate and chromium picolinate on apoptosis induction in the HBL-100 human mammary epithelial cells (MECs).
Methods: HBL-100 cells were treated with chromium nicotinate or chromium picolinate at a concentration of 10 μg/L for 1, 3, and 6 hours. Apoptosis was evaluated using laser scanning cytometry (LSC) to quantify subG1 phase cells, and immunofluorescence staining for expression of apoptotic markers (BAX and the 89 kDa fragment of cleaved PARP).
Key Results
· Chromium picolinate significantly induced apoptosis, demonstrated by an increased percentage of cells in subG1 phase, upregulation of BAX expression, and an increase in cleaved PARP.
· Chromium nicotinate did not induce significant apoptosis. Only a slight increase in BAX expression was observed, with no notable changes in subG1 cell population or PARP cleavage.

Custom Q&A

What is the molecular formula of Chromium nicotinate?

The molecular formula of Chromium nicotinate is C18H12CrN3O6.

What are the synonyms for Chromium nicotinate?

The synonyms for Chromium nicotinate are Chromium(III) nicotinate, 64452-96-6, and chromium(3+);pyridine-3-carboxylate.

What is the molecular weight of Chromium nicotinate?

The molecular weight of Chromium nicotinate is 418.3 g/mol.

What is the parent compound of Chromium nicotinate?

The parent compound of Chromium nicotinate is Nicotinic acid (CID 938).

What are the component compounds of Chromium nicotinate?

The component compounds of Chromium nicotinate are Chromium (CID 23976) and Nicotinic acid (CID 938).

When was Chromium nicotinate created?

Chromium nicotinate was created on October 25, 2006.

When was Chromium nicotinate last modified?

Chromium nicotinate was last modified on October 21, 2023.

What is the IUPAC Name of Chromium nicotinate?

The IUPAC Name of Chromium nicotinate is chromium(3+);pyridine-3-carboxylate.

What is the InChIKey of Chromium nicotinate?

The InChIKey of Chromium nicotinate is MSPQQAUTCRWLGR-UHFFFAOYSA-K.

What is the CAS number of Chromium nicotinate?

The CAS number of Chromium nicotinate is 64452-96-6.