Domperidone

• Catalog Number: ACM57808669
• Product Name: Domperidone
• CAS: 57808-66-9
• Category: Main Products
• Synonyms: 2h-benzimidazol-2-one,1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzi;5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidaz;kw-5338;midazol-1-yl)propyl)-4-piperidinyl)-;DOMPERIDONE;4-(5-chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine;ALPHA-[2-(DIISOPROPYLAMINO)ETHYL]-ALPHA-PHENYL-2-PYRIDINE-ACETAMIDE;5-CHLORO-1-[1-[3-(2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOL-1-YL)PROPYL]-4-PIPERIDINYL]-1,3-DIHYDRO-2H-BENZ-IMIDAZOL-2-ONE
• IUPAC Name: Domperidone
• Molecular Weight: 425.91
• Molecular Formula: C₂₂H₂₄ClN₅O₂
• Melting Point: 240-244°C
• Density: 1.341 g/cm³
• Appearance: solid
• Exact Mass: 425.16200
• Hazard Statements: Xn
• Safety Description: 26-36
• Stability: Stable. Incompatible with strong oxidizing agents.
• Supplemental Hazard Statements: H361-H360
• Symbol: GHS08
• WGK Germany: 3

Custom Q&A

What is the molecular formula of domperidone?

The molecular formula of domperidone is C22H24ClN5O2.

What is the molecular weight of domperidone?

The molecular weight of domperidone is 425.9 g/mol.

What is the IUPAC name of domperidone?

The IUPAC name of domperidone is 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one.

What is the InChIKey of domperidone?

The InChIKey of domperidone is FGXWKSZFVQUSTL-UHFFFAOYSA-N.

What are the synonyms of domperidone?

The synonyms of domperidone are Motilium, Domperidona, and Domperidonum.

What is the role of domperidone?

Domperidone has the role of being an antiemetic and a dopaminergic antagonist.

What receptors does domperidone block?

Domperidone is a specific blocker of dopamine receptors.

What are the uses of domperidone?

Domperidone is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism.

How does domperidone work?

Domperidone binds to dopamine receptor D2 (D2R) expressed by peripheral neurons, inhibiting dopamine binding and D2R-mediated signaling. This helps relieve various gastrointestinal symptoms such as nausea and vomiting.

What are the identifiers for domperidone?

The CAS number for domperidone is 57808-66-9. Other identifiers include CAS Common Chemistry, ChemIDplus, DrugBank, DTP/NCI, EPA DSSTox, European Chemicals Agency (ECHA), FDA Global Substance Registration System (GSRS), and Human Metabolome Database (HMDB).