ARV-110

• CAS: 2222112-77-6
• Catalog Number: ACM-MG-2222112776
• Category: Molecular Glues
• Molecular Weight: 812.30
• Molecular Formula: C41H43ClFN9O6
• Description: ARV-110 is a CRBN-based PROTAC protein degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the androgen receptor (AR).
• Synonyms: Bavdegalutamide; N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide
• IUPAC Name: N-[4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindol-5-yl]piperazin-1-yl]methyl]piperidin-1-yl]pyridazine-3-carboxamide
• SMILES: C1CC(CCC1NC(=O)C2=NN=C(C=C2)N3CCC(CC3)CN4CCN(CC4)C5=C(C=C6C(=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O)F)OC8=CC(=C(C=C8)C#N)Cl
• InChI: InChI=1S/C41H43ClFN9O6/c42-31-19-28(4-1-25(31)22-44)58-27-5-2-26(3-6-27)45-38(54)33-7-9-36(48-47-33)51-13-11-24(12-14-51)23-49-15-17-50(18-16-49)35-21-30-29(20-32(35)43)40(56)52(41(30)57)34-8-10-37(53)46-39(34)55/h1,4,7,9,19-21,24,26-27,34H,2-3,5-6,8,10-18,23H2,(H,45,54)(H,46,53,55)
• InChI Key: CLCTZVRHDOAUGJ-UHFFFAOYSA-N
• Solubility: Soluble in DMSO (25 mg/ml with warming)
• Appearance: Pale yellow solid
• Shipping: Room temperature
• Stability: Stable for up to 1 year when stored as supplied at -20 °C. Solutions in DMSO may be stored at -20 °C for up to 3 months.
• Storage Conditions: Store at -20 °C