N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide

• CAS: 1892-57-5
• Catalog Number: ACM1892575
• Category: Main Products
• Molecular Weight: 155.24
• Molecular Formula: C₈H₁₇N₃
• Synonyms: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide; N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide; N-[(dimethylamino)propyl]-N-ethylcarbodiimide; N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N-3-(N,N-dimethylamino)propylcarbodiimide; 3-dimethylaminopropyl ethyl carbodiimide; N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine; EDC polymer-bound; 1,3-Propanediamine,N-(ethylcarbonimidoyl)-N,N-dimethyl; 3-(ethyliminomethyleneamino)-N,N-dimethyl-propan-1-amine; EDAC; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide; 1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE
• IUPAC Name: 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine
• SMILES: CCN=C=NCCCN(C)C
• InChI Key: LMDZBCPBFSXMTL-UHFFFAOYSA-N
• Boiling Point: 197.7ºC at 760 mmHg
• Melting Point: 115ºC
• Flash Point: 73.4ºC
• Density: 0.877
• Appearance: clear, liquid
• EC Number: 217-579-2
• Exact Mass: 155.14200
• Hazard Statements: C:Corrosive
• Packing Group: III
• Safety Description: S26-S36/37/39-S45
• WGK Germany: 3

Case Study

EDC/NHS-Enabled Self-Crosslinked Hydrogels for Targeted Drug Delivery

Shahzad, Khurram, et al. International Journal of Biological Macromolecules 308 (2025): 142256.

Conventional hydrogel crosslinkers often exhibit toxicity, poor biodegradability, and limited water solubility, restricting their utility in biomedical applications like tumor-targeted drug delivery. The work underlined the use of N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide/N-Hydroxysuccinimide (EDC/NHS) for crosslinking to make the biocompatible hydrogel to be used for biomedical applications, such as tumor-targeted delivery. The synthesized hydrogel is referred to as self-crosslinked carboxymethyl chitosan hydrogel (CMCH HG). The work also presented the composites' synthesis by mixing with gelatin (CMCH/GL HG) and polyethylene glycol-functionalized graphene oxide (CMCH/GL/PEG-GO HG).
Synthesis Approach: CMCH HG was prepared via EDC/NHS coupling chemistry without toxic crosslinkers. CMCH/GL HG and CMCH/GL/PEG-GO HG composites were developed to augment physicochemical properties.
Key Findings:
· Controlled Release of Drug: CMCH/GL/PEG-GO HG could release only 30% of the drug (berberine chloride) in 12 hours, and 39% was released after 96 hours.
· Multifunctional Property: The composites possess good antioxidant activity, anticancer properties, and biodegradability with minimal toxicity.
· Self-Supported Structure: The use of EDC crosslinking was able to form a hydrogel with a stable network structure, and the crosslinking process did not reduce the biocompatibility of the hydrogel.