Oxyfedrine hydrochloride

Name: Oxyfedrine hydrochloride
SKU: ACM16777427
Rating: 5 (1 reviews)

CAS

16777-42-7

Catalog Number

ACM16777427

Category

Main Products

Molecular Weight

349.85

Molecular Formula

C19H24ClNO3

COA MSDS SDS Spec Sheet

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Specification

Synonyms

Oxyfedrine HCl

Appearance

White Solid

Oxyfedrine Hydrochloride Combined with Tetracycline to Enhance the Efficacy of Antibiotics

Mazumdar, Kaushiki, et al. Biological and Pharmaceutical Bulletin, 2005, 28(4), 713-717.

Oxyfedrine hydrochloride exhibited strong antibacterial effects in vitro tests against 501 types of Gram-positive and Gram-negative bacteria. This research examined if this drug improves antibiotic performance when used together with antibiotics. The key findings are as follows:
· Distinct and statistically significant synergism (p<0.01) was detected between oxyfedrine and tetracycline through disc diffusion tests, in comparison to their individual effects.
· The checkerboard analysis yielded a fractional inhibitory concentration (FIC) index of 0.37, further confirming the synergistic interaction of this combination.
· This drug pair of oxyfedrine hydrochloride and tetracycline was subsequently administered to infected mice, with the mouse-protection tests showing significant synergism (p<0.0001) based on Student's t-test.
· Therefore, this synergistic duo may enhance the efficacy of extended antibiotic treatment for various microbial infections, potentially offering new strategies to combat drug-resistant bacterial strains.

Spectrophotometric Determination of Oxyfedrine Hydrochloride in Tablets

Rani, E. Mallapu. World Journal of Pharmaceutical Research, 2017, 6(13), 451-458.

The current cerimetric method is an innovative spectrophotometric approach for quantifying oxyfedrine in pharmaceutical formulations. This method relies on a charge transfer complexation reaction involving the heterocyclic compound.
· Method Procedure
It entails oxidizing oxyfedrine with a known excess of cerium IV sulfate in an acidic medium, followed by the treatment of any unreacted cerium IV sulfate with iron II sulfate. After a five-minute reaction, the resulting iron III sulfate solution is combined with 1M ammonium thiocyanate, producing a blood-red iron III thiocyanate complex. This complex, formed under standardized conditions, is measured at 560 nm against a reagent blank.
A calibration graph for oxyfedrine hydrochloride is constructed by plotting absorbance against drug solution concentration, revealing linearity within the 50-250 µg/mL range, in accordance with Beer's law.
· Method Validation
The analysis results were statistically validated and confirmed through recovery studies. This method was effectively employed to measure oxyfedrine in tablet formulations.

What is the molecular formula of Oxyfedrine hydrochloride?

The molecular formula of Oxyfedrine hydrochloride is C19H24ClNO3.

What is the molecular weight of Oxyfedrine hydrochloride?

The molecular weight of Oxyfedrine hydrochloride is 349.8 g/mol.

What is the IUPAC name of Oxyfedrine hydrochloride?

The IUPAC name of Oxyfedrine hydrochloride is 3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-(3-methoxyphenyl)propan-1-one hydrochloride.

What is the InChIKey of Oxyfedrine hydrochloride?

The InChIKey of Oxyfedrine hydrochloride is JMUPNNYLJGSMPK-JPJJPTBZSA-N.

What is the Canonical SMILES of Oxyfedrine hydrochloride?

The Canonical SMILES of Oxyfedrine hydrochloride is CC(C(C1=CC=CC=C1)O)NCCC(=O)C2=CC(=CC=C2)OC.Cl.

What is the CAS number of Oxyfedrine hydrochloride?

The CAS number of Oxyfedrine hydrochloride is 16777-42-7.

What are the synonyms of Oxyfedrine hydrochloride?

The synonyms of Oxyfedrine hydrochloride are OXYFEDRINE HYDROCHLORIDE, 16777-42-7, Oxyfedrine HCl, Ildamen, and Modacor.

What are the medical applications of Oxyfedrine hydrochloride?

Oxyfedrine hydrochloride is used in the treatment of angina pectoris, heart failure, conduction defects, and myocardial infarction.

What is the role of Oxyfedrine hydrochloride in the body?

Oxyfedrine hydrochloride is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.

What are the chemical and physical properties of Oxyfedrine hydrochloride?

The molecular weight of Oxyfedrine hydrochloride is 349.8 g/mol, it has a hydrogen bond donor count of 3, a hydrogen bond acceptor count of 4, and a rotatable bond count of 8. It also has an exact mass of 349.1444713 g/mol and a topological polar surface area of 58.6Å².

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