Sucrose octasulfate potassium salt

• CAS: 73264-44-5
• Catalog Number: ACM73264445
• Category: Main Products
• Molecular Weight: 1287.53
• Molecular Formula: C₁₂H₁₄K₈O₃₅S₈
• Synonyms: potassium sucrose octasulphate; potassium salt of sucrose octasulfate; sucrose sulfate; Sucrosofate PotassiuM; sucrose octasulfate potassium salt; potassium sucrose octasulfate
• IUPAC Name: octapotassium;[(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-disulfonatooxy-2,5-bis(sulfonatooxymethyl)oxolan-2-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)oxan-4-yl]sulfate
• SMILES: C(C1C(C(C(C(O1)OC2(C(C(C(O2)COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+]
• InChI Key: XISWAUUBQBEDFB-QRDGSJRXSA-F
• Melting Point: >230ºC
• Appearance: white solid
• EC Number: 615-946-5
• Exact Mass: 1285.42000
• Hazard Statements: Xi
• Safety Description: 26-37/39

Case Study

Potassium Sucrose Octasulfate: Delivered via Double-Network Polyhipe Hydrogel for Accelerated Diabetic Wound Healing

Wang, Zhiwei, et al. Regenerative Biomaterials 11 (2024): rbae024.

This study used sucrose octasulfate potassium salt (hereafter PSO) as the active agent in a porous double-network hydrogel designed by a high internal phase emulsion (HIPE) approach. The PSO-loaded p(MMA-co-AM)/PVA@PSO hydrogel combined an interconnected polyHIPE architecture, strong mechanical integrity, and high drug-loading/release capability. In vitro and in vivo evaluations showed that the hydrogel system provided biocompatible, sustained delivery of PSO and promoted multiple healing endpoints in diabetic wounds (reduced MMP-9 activity, enhanced angiogenesis and growth factor secretion, increased collagen deposition, and accelerated re-epithelialization).
Preparation method and procedure:
· HIPE technique: The continuous polymer phase was formed via a high internal phase emulsion to create a polyHIPE microstructure-resulting in an interconnected porous morphology with high porosity and large specific surface area.
· PSO incorporation: PSO was added to the dispersed (internal) phase during the initial synthesis stage to produce p(MMA-co-AM)/PVA@PSO hydrogels with varying PSO loading. The reported PSO loadings tested were in the range 0.1-0.5 g (added during the first phase of synthesis).
· Processing details: PVA (0.8 g) was dissolved in deionized water with stirring at 80 °C. Monomers (MMA, AM), crosslinker (DVB), initiator (potassium persulfate), surfactant (Span80) and water were combined following the study's formulation proportions. The mixture was polymerized at 60 °C to form the HIPE prepolymer, then subjected to freezing at -20 °C for 6 hours and thawing at 25 °C for 2 hours. The hydrogel network was established by repeating freeze-thaw cycles five times.

Application of Potassium Sucrose Octasulfate in a Hypertonic Solution for Nasal Obstruction

Passali, Desiderio, et al. SpringerPlus 2.1 (2013): 668.

Nasal obstruction is one of the most frequent symptoms of upper respiratory diseases. Its treatment at the level of symptomatic supportive therapy is reduced to washing procedures. The aim of the study was to determine the clinical effectiveness of the hypertonic nasal solution containing silver sucrose octasulfate (IASOS) and potassium sucrose octasulfate (KSOS) in the treatment of patients with moderate severity of persistent nasal obstruction. The composition of the test solution is due to the synergistic effect of the antimicrobial action of IASOS and carbohydrate-induced microbial anti-adhesion and mucosal trophic properties of KSOS.
Methodology: A clinical study was conducted with 55 patients (aged 25-70) suffering from obstructive rhinopathy with persistent nasal congestion. Participants were randomly assigned to use either the hypertonic solution or an isotonic solution for 20 days. Assessments were performed at baseline (T0), day 10 (T10), and day 20 (T20).
Key Results:
· The AAR analysis demonstrated that the SILSOS group experienced a statistically significant (p<0.05) improvement in expiratory nasal airflow at both T10 and T20 compared to baseline.
· Mucociliary Clearance: While no significant change in mucociliary transport time (MCTt) was observed, the mean Mucociliary Clearance (MCC) values showed significant improvement by T20.
· Symptomatic Relief: The total VAS score indicated progressive improvement throughout the entire treatment period.
· The therapeutic benefit was sustained post-treatment. At the 30-day follow-up, only 3 patients from the hypertonic solution group reported a return of nasal obstruction, which was mild in form.

Custom Q&A

What is the molecular formula of sucrose octasulfate potassium salt?

The molecular formula of sucrose octasulfate potassium salt is C12H14K8O35S8.

What are some synonyms for sucrose octasulfate potassium salt?

Some synonyms for sucrose octasulfate potassium salt are potassium sucrose octasulfate, Sucrosofate potassium anhydrous, and Sucrose octasulphate potassium salt.

What is the CAS number for sucrose octasulfate potassium salt?

The CAS number for sucrose octasulfate potassium salt is 73264-44-5.

What is the IUPAC name of sucrose octasulfate potassium salt?

The IUPAC name of sucrose octasulfate potassium salt is octapotassium;[(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-disulfonatooxy-2,5-bis(sulfonatooxymethyl)oxolan-2-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)oxan-4-yl] sulfate.

What is the InChI key of sucrose octasulfate potassium salt?

The InChI key of sucrose octasulfate potassium salt is XISWAUUBQBEDFB-QRDGSJRXSA-F.

How many potassium ions are present in sucrose octasulfate potassium salt?

There are 8 potassium ions present in sucrose octasulfate potassium salt.

What is the EC number of sucrose octasulfate potassium salt?

The EC number of sucrose octasulfate potassium salt is 615-946-5.

What is the computed SMILES notation for sucrose octasulfate potassium salt?

The computed SMILES notation for sucrose octasulfate potassium salt is C(C1C(C(C(C(O1)OC2(C(C(C(O2)COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].

What is the computed InChI of sucrose octasulfate potassium salt?

The computed InChI of sucrose octasulfate potassium salt is InChI=1S/C12H22O35S8.8K/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18;;;;;;;;/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;;;;;;;/q;8*+1/p-8/t4-,5-,6-,7-,8+,9-,10+,11-,12+;;;;;;;;/m1......../s1.

When was the modify date of sucrose octasulfate potassium salt?

The modify date of sucrose octasulfate potassium salt is 2023-08-26.