Methoxamine hydrochloride,99%

• CAS: 61-16-5
• Catalog Number: ALC-FP-61165
• Category: Featured Products
• Molecular Weight: 247.72 g/mol
• Molecular Formula: C11H17NO3·HCl
• Appearance: Off white to white solid
• Sample Lot No.: A22ZC0825
• Single Impurity: <0.3% (Max)
• Water Content: <0.5% (KF)

Case Study

Methoxamine Hydrochloride for Electrochemical Amino- and Methoxymethylation Reactions

Zha X, et al. Green Synthesis and Catalysis, 2025.

Methoxamine hydrochloride was experimentally applied as a dual methylene and heteroatom source in an electrochemical amino- or methoxymethylation of weak nucleophiles. In a constant-current electrosynthetic setup, amide or heteroaryl substrates were reacted with excess methoxamine hydrochloride in acetonitrile, using ammonium iodide as a supporting electrolyte. Electrolysis was conducted at room temperature under air with a graphite anode and platinum cathode, enabling direct C-N or C-O bond formation via an in situ Mannich-type process. This method allowed weakly nucleophilic amides and sulfonamides to undergo efficient functionalization without pre-activation. Notably, by increasing current and reaction time, primary amides were selectively converted to N-(methoxymethyl)amide derivatives. The procedure demonstrates methoxamine hydrochloride's practical utility in scalable, reagent-economical electrochemical C-H functionalization.