Lenalidomide hydrochloride

• CAS: 1243329-97-6
• Catalog Number: ACM-MG-1243329976
• Category: Molecular Glues
• Molecular Weight: 295.72
• Molecular Formula: C13H14ClN3O3
• Description: Lenalidomide hydrochloride (CC-5013 hydrochloride), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hydrochloride is an orally active immunomodulator. Lenalidomide hydrochloride (CC-5013 hydrochloride) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hydrochloride (CC-5013 hydrochloride) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.
• Synonyms: CC-5013 hydrochloride
• IUPAC Name: 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;hydrochloride
• SMILES: O=C1C2=CC=CC(N)=C2CN1C(C(N3)=O)CCC3=O.[H]Cl
• InChI: InChI=1S/C13H13N3O3.ClH/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18;/h1-3,10H,4-6,14H2,(H,15,17,18);1H
• InChI Key: RYWZLJSDFZVVTD-UHFFFAOYSA-N
• EC Number: 815-073-1
• Shipping: Generally, shipped at room temperature in continental US; may vary elsewhere.