CAS
1227162-34-6 Purity
>99%
1227162-34-6 Purity
>99%
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Taselisib
CAS
1282512-48-4
Catalog Number
ACM-MG-1282512484
Category
Molecular Glues
Molecular Weight
460.54
Molecular Formula
C24H28N8O2
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Specification
Description
Taselisib has a dual mechanism of action, both blocking kinase signaling and inducing down-regulation of the mutant p110alpha protein level in a dose-dependent and time-dependent manner. The taselisib-induced degradation of mutant p110a protein is ubiquitin-mediated and proteasome-dependent.
Synonyms
GDC-0032
IUPAC Name
2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide
SMILES
CC(C)N1N=C(C)N=C1C1=CN2CCOC3=CC(=CC=C3C2=N1)C1=CN(N=C1)C(C)(C)C(N)=O
InChI
InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
InChI Key
BEUQXVWXFDOSAQ-UHFFFAOYSA-N
Solubility
Soluble in DMSO, DMF
Appearance
White solid
Shipping
Room temperature
Storage Conditions
Refrigerated
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