CAS
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LC-04-045
Catalog Number
ACM-MG-00071
Category
Molecular Glues
Molecular Weight
566.05
Molecular Formula
C32H28ClN5O3
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Specification
Description
LC-04-045 is a selective NIMA-related kinase 7 (NEK7) molecular glue degrader. LC-04-045 induces NEK7 degradation via the CRBN-based ubiquitin-proteasome system, dependent on the glycine 57-containing degron motif.
SMILES
O=C([C@@H](N(CC1=C2C=CC(C3=CN=C4CN(CC5=CC=CC=C5C6=CC=CC=C6Cl)CCN43)=C1)C2=O)CC7)NC7=O
Appearance
White to off-white solid
Shipping
Room temperature; may vary elsewhere.
Storage Conditions
Store at -20 °C
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