Rahman O1, Takano A2, Amini N2, Dahl K2, Kanegawa N2, Långström B3, Farde L2, Halldin C4.
Nucl Med Biol. 2015 Nov;42(11):893-8. doi: 10.1016/j.nucmedbio.2015.07.003. Epub 2015 Jul 15.INTRODUCTION: The selective dopamine D2 receptor antagonist raclopride is usually labeled with carbon-11 using [(11)C]methyl iodide or [(11)C]methyl triflate for use in the quantification of dopamine D2 receptors in human brain. The aim of this work was to label raclopride at the carbonyl position using [(11)C]carbon monoxide chemistry and to compare ([(11)C]carbonyl)raclopride with ([(11)C]methyl)raclopride in non-human primate (NHP) using PET with regard to quantitative outcome measurement, metabolism of the labeled tracers and protein binding. Read More