Ganciclovir sodium

• Catalog Number: ACM107910758
• Product Name: Ganciclovir sodium
• CAS: 107910-75-8
• Category: Inhibitors
• Description: Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
• Synonyms: GANCICLOVIR SODIUM;2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6h-purin-6-one sodium salt;9-[[1-(Hydroxymethyl)-2-hydroxyethoxy]methyl]-2-amino-9H-purine-6(1H)-one/sodium,(1:1) salt;Ganciclovir monosodium salt;6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt;6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt;Rs 21592 sodium;Unii-02L083W284
• Molecular Weight: 277.21
• Molecular Formula: C₉H₁₂N₅NaO₄

Custom Q&A

What is the molecular formula of Ganciclovir sodium?

The molecular formula of Ganciclovir sodium is C9H12N5NaO4.

What is the molecular weight of Ganciclovir sodium?

The molecular weight of Ganciclovir sodium is 277.21 g/mol.

What is the IUPAC name of Ganciclovir sodium?

The IUPAC name of Ganciclovir sodium is sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate.

What is the InChIKey of Ganciclovir sodium?

The InChIKey of Ganciclovir sodium is JJICLMJFIKGAAU-UHFFFAOYSA-M.

What is the canonical SMILES representation of Ganciclovir sodium?

The canonical SMILES representation of Ganciclovir sodium is C1=NC2=C(N1COC(CO)CO)N=C(N=C2[O-])N.[Na+].

What is the CAS number of Ganciclovir sodium?

The CAS number of Ganciclovir sodium is 84245-13-6.

What is the ChEMBL ID for Ganciclovir sodium?

The ChEMBL ID for Ganciclovir sodium is CHEMBL1200850.

How does Ganciclovir sodium function as an antiviral?

Ganciclovir sodium is a prodrug that is phosphorylated and converted into its active metabolite ganciclovir-5-triphosphate in infected cells. Ganciclovir-5-triphosphate competes with nucleotide triphosphates for viral DNA polymerase, inhibiting viral DNA replication.

What is Ganciclovir sodium FDA-approved for?

Ganciclovir sodium is FDA-approved for the treatment of cytomegalovirus retinitis in immunocompromised adults and for the prevention of CMV disease in organ transplant recipients at risk for CMV diseases.

What is the chemical structure of Ganciclovir sodium?

The chemical structure of Ganciclovir sodium includes a purine nucleoside analog with antiviral activity against cytomegalovirus.