Carboxyethylsilanetriol na salt 25% in water

• CAS: 18191-40-7
• Catalog Number: ACM18191407
• Category: Main Products
• Molecular Weight: 174.159
• Molecular Formula: C₃H₇O₅Si.Na
• Synonyms: CARBOXYETHYLSILANETRIOL NA SALT 25% IN WATER;25% IN WATER;CARBOXYETHYLSILANETRIOL, SODIUM SALT: 25% IN WATER;Carboxyethylsilanetriol na salt 25% in water ,0%;Propanoic acid, 3-(trihydroxysilyl)-, disodiuM salt;CARBOXYETHYLSILANETRIOL, DISODIUM SALT, 25% in water;CARBOXYETHYLSILANETRIOL, DISODIUM SALT
• IUPAC Name: sodium;3-trihydroxysilylpropanoate
• SMILES: C(C[Si](O)(O)O)C(=O)[O-].[Na+]
• InChI Key: INEPLXDYNFVQCD-UHFFFAOYSA-M
• Boiling Point: 100°C
• Flash Point: 193.6ºC
• Exact Mass: 173.99600

Case Study

Preparation of SiO2 Nanoparticles for Drug Delivery Using Sodium Carboxyethylsilanetriol

Zhang, Peng, et al. Talanta, 2015, 134, 501-507.

This work demonstrates a pH-responsive drug delivery system based on doxorubicin-tethered fluorescent silica nanoparticles (DOX-Hyd@FSiNPs). The system couples DOX to FSiNPs via an acid-labile hydrazone linker, and the fluorescence properties allow the nanoparticles to be tracked inside cells. In vitro experiments showed that DOX-Hyd@FSiNPs can effectively release doxorubicin and successfully reduce the viability of HeLa cells in an acidic environment. Carboxyethylsilanetriol Na salt (25% in water) is the key raw material for carboxylic acid modification of FSiNPs.
· Synthesis of FSiNPs and carboxylic acid-modified FSiNPs
Fluorescein isothiocyanate (FITC) was conjugated with aminopropyltriethoxysilane (APTES) in n-hexanol to form FITC-APTES, followed by incorporation into a water-in-oil microemulsion system containing Triton X-100, cyclohexane, and tetraethyl orthosilicate (TEOS). Ammonium hydroxide initiated silica nanoparticle formation, which was isolated via acetone precipitation, centrifugation, and washing. The obtained FSiNPs were carboxylated using carboxyethylsilanetriol Na salt under acidic conditions, purified, and stored in aqueous suspension.
· Synthesis of doxorubicin-tethered FSiNPs
Carboxylic acid-functionalized FSiNPs were activated with EDC/NHS to enable hydrazine grafting via amide bonding. The hydrazine-modified nanoparticles (hydrazine@FSiNPs) were reacted with DOX in methanol, forming hydrazone-linked DOX-Hyd@FSiNPs. Unbound DOX was removed through repeated centrifugation and methanol washing. Drug-loading efficiency was quantified by UV-vis analysis of the supernatant, while the final conjugate was vacuum-dried for storage.

Functionalization of ZnO Chip Devices with Carboxyethylsilanetriol Sodium Salt for Exosome Detection

Chen, Zhen, et al.Biosensors and Bioelectronics, 2018, 122, 211-216.

A ZnO nanowire-coated three-dimensional (3D) scaffold chip device is proposed for efficient immunocapture and classical visible and colorimetric detection of exosomes with a minimum detectable concentration of 2.2 × 10⁴ particles/μL. The ZnO chip device consists of a 3D polydimethylsiloxane (PDMS) scaffold skeleton covered with free-standing ZnO nanowire arrays (functionalized with carboxylic acids and CD63 monoclonal antibody).
Functionalization of ZnO chip device
Initially, the chip underwent plasma treatment for a duration of 3 minutes. The chip was exposed to a 5% carboxyethylsilanetriol sodium salt solution which incubated for 4 hours to achieve carboxyl coupling. After rinsing with water, a boric acid buffer (10 mM, pH 7.4) containing 25 mM 1-(3-(Dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (EDC) and 0.5 mg/mL streptavidin (SA) was pumped into the chip and left to react on ice for 4 hours. Any excess EDC and SA were then removed, and a 10 μg/mL biotin-labeled mouse anti-human CD63 monoclonal antibody was added to the chip for incubation for 1 hour. Finally, the chip was blocked using a solution of 5% BSA and 0.2% Tween-20, and then stored at 4 °C until needed.