Burhardt MN1, Ahlburg A, Skrydstrup T.
J Org Chem. 2014 Dec 19;79(24):11830-40. doi: 10.1021/jo5009965. Epub 2014 Jun 17.A catalytic protocol for synthesis of thioesters from aryl, vinyl, and benzyl bromides as well as benzyl chlorides was developed using only stoichiometric amounts of carbon monoxide, produced from a solid CO precursor inside a two-chamber system. As a catalytic system, the combination of bis(benzonitrile) palladium(II) chloride and Xantphos furnished the highest yields of the desired compounds, along with the weak base, NaOAc, in anisole at 120 °C. Read More