Original Article:
Moving polyvinyl pyrrolidone electrospun nanofibers and bioprinted scaffolds toward multidisciplinary biomedical applications
Mallesh Kurakula, et al.
European Polymer Journal, 2020, 136, 109919.
10.1016/j.eurpolymj.2020.109919
Due to its multifunctional properties, polyvinylpyrrolidone (PVP) has been explored and widely used to fabricate a wide range of biomedical products through electrospinning, 3D/4D printing, and other techniques. As we all know, PVP has the following characteristics:
• Biological activity
• Water soluble
• Amphipathic
• Non-toxic
• Temperature resistance
• Ph stability
• Chemical stability
• Biodegradability
• Biocompatibility
The importance of PVP has been proved with the introduction of several synthetic procedures, production of PVP in various molecular weights and different grades, commercialization of homopolymers, copolymers and crosslinked PVP. Here, Mallesh Kurakula et al. review the progress and trends in the PVP use in designing multidisciplinary biomedical products via advanced approaches. This article details key research aspects and promising potentials of PVP-based nanoscaffolds in a variety of biomedical implants (orthopedic, dental, vaginal, breast), regenerative tissue engineering (neural, cardiac, and pancreatic tissue), therapeutic drug delivery. Taking the application of PVP in therapeutic drug delivery as an example, a mechanically strong nanofibrous mat has been developed with hydrogen bonding between PVP and tannic acid. Compared with pristine PVP fibers, the nanofibrous mats exhibit significantly enhanced tensile strength, Young's modulus, and toughness, as well as strong antioxidant activity.
Chemicals Related in the Paper:
| Catalog Number | Product Name | Structure | CAS Number | Price |
|---|---|---|---|---|
| ACM25655415 | Polyvinyl pyrrolidone |  |
25655-41-5 | Price |
