4-Iodopyrazole

• CAS: 3469-69-0
• Catalog Number: ACM3469690
• Category: Main Products
• Molecular Weight: 193.97
• Molecular Formula: C₃H₃IN₂
• Synonyms: 4-IODOPYRAZOLE;4-IODO-1H-PYRAZOLE;1H-PYRAZOLE, 4-IODO-;4-IODOPYRAZOLE 99%;4-Iodopyrazole ,98%;4-Lodophrazole;4-LODO PYRAZOLE;4-Iodopyrazole, 97+%
• IUPAC Name: 4-iodo-1H-pyrazole
• SMILES: C1=C(C=NN1)I
• InChI Key: LLNQWPTUJJYTTE-UHFFFAOYSA-N
• Boiling Point: 291.9ºCat 760 mmHg
• Melting Point: 108-110°C(lit.)
• Flash Point: 130.3ºC
• Density: 2.335 g/cm³
• Appearance: off-white crystalline powder
• EC Number: 222-434-1
• Exact Mass: 193.93400
• Hazard Statements: Xn,Xi
• Safety Description: 26
• Supplemental Hazard Statements: H301-H302-H315-H319-H335
• Symbol: GHS06,GHS07
• WGK Germany: 3

Case Study

4-Iodopyrazole for the Inhibition of Hepatic Aldehyde Dehydrogenase in Experimental Models

Koe BK, et al. Biochemical Pharmacology, 1975, 24(6), 23-727.

Chronic administration of 4-iodopyrazole provides a unique experimental approach to probe ethanol metabolism in vivo. In controlled mouse studies, the compound was delivered continuously via drinking water, enabling sustained systemic exposure. Unlike acute dosing, which primarily reduced alcohol dehydrogenase activity without altering aldehyde dehydrogenase, chronic ingestion resulted in a marked suppression of hepatic aldehyde dehydrogenase activity. This metabolic blockade was validated by the accumulation of acetaldehyde in blood following ethanol challenge, confirming impaired enzymatic clearance. Experimental protocols demonstrated reproducibility across multiple treatment cycles, with enzymatic assays from excised livers confirming activity modulation. Additionally, behavioral studies revealed reduced ethanol preference in C57BL mice, directly correlating biochemical inhibition with altered consumption behavior. These findings position 4-iodopyrazole as a valuable tool for mechanistic investigations of alcohol metabolism and aldehyde dehydrogenase-dependent pathways in pharmacological research.

Custom Q&A

What is the molecular formula of 4-iodopyrazole?

The molecular formula of 4-iodopyrazole is C3H3IN2.

What is the molecular weight of 4-iodopyrazole?

The molecular weight of 4-iodopyrazole is 193.97 g/mol.

What are some synonyms for 4-iodopyrazole?

Some synonyms for 4-iodopyrazole include 4-Iodo-1H-pyrazole and 4-iodo pyrazole.

What is the IUPAC name for 4-iodopyrazole?

The IUPAC name for 4-iodopyrazole is 4-iodo-1H-pyrazole.

What is the InChIKey of 4-iodopyrazole?

The InChIKey of 4-iodopyrazole is LLNQWPTUJJYTTE-UHFFFAOYSA-N.

What is the CAS number of 4-iodopyrazole?

The CAS number of 4-iodopyrazole is 3469-69-0.

How many hydrogen bond donor counts does 4-iodopyrazole have?

4-iodopyrazole has 1 hydrogen bond donor count.

What is the topological polar surface area of 4-iodopyrazole?

The topological polar surface area of 4-iodopyrazole is 28.7Ų.

Is 4-iodopyrazole a canonicalized compound?

Yes, 4-iodopyrazole is a canonicalized compound.