4-Iodophenylboronic acid is a versatile white crystalline powder that serves as a key reagent in a variety of advanced chemical reactions. It plays a crucial role in copper-mediated ligandless aerobic fluoroalkylation and palladium-catalyzed aerobic oxidative cross-coupling reactions. Its utility extends to the realm of recyclable magnetic-nanoparticle-supported palladium catalysis in Suzuki coupling reactions, offering efficient oxidative hydroxylation with copper catalysts. Moreover, it is involved in ligand-free palladium-catalyzed Suzuki-Miyaura cross-coupling and homocoupling processes using gold salts as catalysts. Additionally, 4-Iodophenylboronic acid is employed in ruthenium-catalyzed cross-coupling and CuI-catalyzed Suzuki coupling reactions. It supports complex transformations such as palladium-catalyzed domino Heck-Mizoroki/Suzuki-Miyaura reactions and facilitates manganese triacetate-mediated radical additions of arylboronic acids to alkenes. Beyond these applications, this reagent is integral to the preparation of pleuromutilin derivatives, aimed at ribosomal binding and antibacterial activity via "Click Chemistry," as well as in the development of liquid crystalline polyacetylene derivatives.