2-(4-Morpholino)pyrimidine-5-boronic acid pinacol ester

• CAS: 957198-30-0
• Catalog Number: ACM957198300
• Category: Other Products; Boronic Esters
• Molecular Weight: 291.15
• Molecular Formula: C₁₄H₂₂BN₃O₃

Custom Reviews

May 23, 2023

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High yield preparation of indole derivatives.
Indole derivatives prepared by 2-(4-Morpholino)pyrimidine-5-boronic acid pinacol ester have high pharmacological activity as selective Pim kinase inhibitors.

Synthetic Use

Upstream Synthesis Route 1

• 84539-22-0
• 73183-34-3

• 957198-30-0

Reference: [1] Patent: WO2016/615, 2016, A1, . Location in patent: Paragraph 00730

Downstream Synthesis Route 1

• 957198-30-0
• 583-53-9

• 1253936-67-2

Reference: [1]Patent: WO2010/126811,2010,A1 .Location in patent: Page/Page column 139-140

Downstream Synthesis Route 2

• 957198-30-0
• 1160756-09-1

• 1338377-41-5

Reference: [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 7334 - 7349

Downstream Synthesis Route 3

• 957198-30-0
• 1453861-34-1

• 1453862-03-7

Reference: [1]Patent: WO2013/128378,2013,A1 .Location in patent: Page/Page column 147; 148

* For details of the synthesis route, please refer to the original source to ensure accuracy.