NRX-252114

• CAS: 2763260-39-3
• Catalog Number: ACM-MG-2763260393
• Category: Molecular Glues
• Molecular Weight: 510.32
• Molecular Formula: C22H12Cl2F3N3O2S
• Description: NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation.
• IUPAC Name: 2-[4-(2,6-dichlorophenyl)sulfanyl-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]-1,3-dihydroisoindole-4-carbonitrile
• SMILES: N#CC1=CC=CC2=C1CN(C(C3=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)NC3=O)=O)C2
• InChI: InChI=1S/C22H12Cl2F3N3O2S/c23-14-5-2-6-15(24)19(14)33-16-7-17(22(25,26)27)29-20(31)18(16)21(32)30-9-12-4-1-3-11(8-28)13(12)10-30/h1-7H,9-10H2,(H,29,31)
• InChI Key: BMQXGPBUQGPLOV-UHFFFAOYSA-N
• Appearance: White to off-white solid
• Shipping: Generally, shipped at room temperature in continental US; may vary elsewhere.
• Storage Conditions: Store at 4 °C