NRX-2663

• CAS: 2763260-34-8
• Catalog Number: ACM-MG-2763260348
• Category: Molecular Glues
• Molecular Weight: 418.33
• Molecular Formula: C20H13F3N2O5
• Description: NRX-2663 is an enhancer of the interaction between beta-catenin and beta-TrCP. NRX-2663 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome.
• IUPAC Name: 3-[[2-oxo-4-phenoxy-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]amino]benzoic acid
• SMILES: OC(=O)C1=CC=CC(NC(=O)C2=C(OC3=CC=CC=C3)C=C(NC2=O)C(F)(F)F)=C1
• InChI: InChI=1S/C20H13F3N2O5/c21-20(22,23)15-10-14(30-13-7-2-1-3-8-13)16(18(27)25-15)17(26)24-12-6-4-5-11(9-12)19(28)29/h1-10H,(H,24,26)(H,25,27)(H,28,29)
• InChI Key: QMARDTCIJVODCK-UHFFFAOYSA-N
• Solubility: Soluble in DMSO, DMF
• Appearance: White solid
• Shipping: Room temperature
• Storage Conditions: Refrigerated