CAS
3026986-17-1 Purity
>99%
3026986-17-1 Purity
>99%
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DEG-77
CAS
3032265-06-5
Catalog Number
ACM-MG-3032265065
Category
Molecular Glues
Molecular Weight
447.44
Molecular Formula
C24H21N3O6
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Specification
Description
DEG-77, is a IKZF2 and CK1α targeted molecular glue, with DC50s of 15.3 nM and 10 nM, respectively. DEG-77 possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h). DEG-77 can be used for acute myeloid leukemia (AML) study.
IUPAC Name
N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-8-methoxy-2H-chromene-3-carboxamide
SMILES
O=C1C2=CC=C(C=C2CN1C3CCC(NC3=O)=O)NC(C4=CC5=C(OC4)C(OC)=CC=C5)=O
InChI
InChI=1S/C24H21N3O6/c1-32-19-4-2-3-13-9-15(12-33-21(13)19)22(29)25-16-5-6-17-14(10-16)11-27(24(17)31)18-7-8-20(28)26-23(18)30/h2-6,9-10,18H,7-8,11-12H2,1H3,(H,25,29)(H,26,28,30)
InChI Key
ZFAKJMUJUNDGEI-UHFFFAOYSA-N
Appearance
Light yellow to green yellow solid
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Store at -20 °C
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