CAS
3030588-01-0 Purity
≥98% (HPLC)
3030588-01-0 Purity
≥98% (HPLC)
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INNO-220
CAS
3032576-92-1
Catalog Number
ACM-MG-3032576921
Category
Molecular Glues
Molecular Weight
400.43
Molecular Formula
C23H20N4O3
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Specification
Description
INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research.
SMILES
CN1N=CC(C2=CC3=C(C(N(C3)C4CCC(NC4=O)=O)=O)C=C2)=C1C5=CC=CC=C5
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Storage Conditions
Please store the product under the recommended conditions.
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