Minocycline hydrochloride

• Catalog Number: ACM13614987
• Product Name: Minocycline hydrochloride
• CAS: 13614-98-7
• Category: Inhibitors
• Description: Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.
• Synonyms: [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride; Minocycline Hydrochloride; Minocycline hydrochloride
• IUPAC Name: (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
• Molecular Weight: 493.94
• Molecular Formula: C₂₃H₂₇N₃O₇·HCl
• Canonical SMILES: CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
• InChI Key: WTJXVDPDEQKTCV-VQAITOIOSA-N
• Boiling Point: 659.4ºC at 760mmHg
• Melting Point: 205-210ºC(dec)
• Flash Point: 352.6ºC
• Appearance: crystalline
• EC Number: 237-099-7
• Exact Mass: 493.16200
• Hazard Statements: Xi:Irritant
• Packing Group: III
• Safety Description: S26-S36
• WGK Germany: 3