Catalog Number
ACM34316159
Product Name
Chelerythrine
Description
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.
Synonyms
Broussonpapyrine; Cheleritrine; Chelerythrin; Chelerythrine chloride; Chelerythrin-Kation; Chelerythrine; Chelerythrin chlorid;
IUPAC Name
1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
Molecular Formula
C21H18ClNO4
Canonical SMILES
C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5
InChI Key
LLEJIEBFSOEYIV-UHFFFAOYSA-N
Hazard Statements
Xn:Harmful;