Chbib C1, Sobczak AJ1, Mudgal M1, Gonzalez C1, Lumpuy D1, Nagaj J1, Stokowa-Soltys K1, Wnuk SF1.
J Sulphur Chem. 2016;37(3):307-327. Epub 2016 Feb 24.4-C-Alkyl/aryl-S-ribosylhomocysteine (SRH) analogues were prepared by coupling of homocysteine with 4-substituted ribofuranose derivatives. The diastereoselective incorporation of the methyl substituent into the 4 position of the ribose ring was accomplished by addition of methylmagnesium bromide to the protected ribitol-4-ulose yielding the 4-C-methylribitol in 85% yield as single 4R diastereomer. ... Read More